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Survival and Functional Outcome after Treatment for Primary Base of Tongue Cancer: A Comparison of Definitive Chemoradiotherapy versus Surgery Followed by Adjuvant Radiotherapy.

 Sangjoon Park  ;  Yeona Cho  ;  Jeongshim Lee  ;  Yoon Woo Koh  ;  Se-Heon Kim  ;  Eun Chang Choi  ;  Hye Ryun Kim  ;  Ki Chang Keum  ;  Kyung Ran Park  ;  Chang Geol Lee 
 Cancer Research and Treatment, Vol.50(4) : 1214-1225, 2018 
Journal Title
 Cancer Research and Treatment 
Issue Date
Base of tongue cancer ; Organ preservation ; Radiotherapy ; Surgery ; Treatment outcome
PURPOSE: The purpose of this study was to compare the clinical and functional outcomes in patients with primary base of tongue (BOT) cancer who received definitive radiotherapy (RT) or surgery followed by radiotherapy (SRT). Materials and Methods: Between January 2002 andDecember 2016, 102 patientswith stage I-IVB primary BOT cancer underwent either definitive RT (n=46) or SRT (n=56), and treatment outcomeswere compared between two groups. The expression of p16 was also analyzed. RESULTS: The RT group had more patients with advanced T stage (T3-4) disease (58.7% vs. 35.7%, p=0.021) and who received chemotherapy (91.3% vs. 37.5%, p < 0.001) than the SRT group. At a median followup of 36.9 months (range, 3.3 to 181.5 months), the 5-year overall survival (OS) and disease-free survival (DFS) were 75.5% and 68.7%, respectively. With respect to treatment group, the 5-year OS and DFS in the RT and SRT groups did not differ significantly (OS, 68.7% vs. 80.5%, p=0.601; DFS, 63.1% vs. 73.1%, p=0.653). In multivariate analysis, OS differed significantly according to p16 expression (p16-negative vs. p16- positive; hazard ratio [HR], 0.145; 95% confidence interval [CI], 0.025 to 0.853; p=0.033). Regarding DFS, p16 expression (p16-negative vs. p16-positive; HR, 0.164; 95% CI, 0.045 to 0.598; p=0.006) showed a significant effect in multivariate analysis. Functional defects (late grade ≥ 3 dysphagia or voice alteration) were more frequently reported in the SRT than in the RT group (16.1% vs. 2.2%, p=0.021). CONCLUSION: Despite advanced disease, patients in the RT group showed comparable survival outcomes and better functional preservation than those in the SRT group.
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1. College of Medicine (의과대학) > Dept. of Otorhinolaryngology (이비인후과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
고윤우(Kho, Yoon Woo)
금기창(Keum, Ki Chang) ORCID logo https://orcid.org/0000-0003-4123-7998
김세헌(Kim, Se Heon)
김혜련(Kim, Hye Ryun) ORCID logo https://orcid.org/0000-0002-1842-9070
이정심(Lee, Jeong Shim)
이창걸(Lee, Chang Geol) ORCID logo https://orcid.org/0000-0002-8702-881X
조연아(Cho, Yeona) ORCID logo https://orcid.org/0000-0002-1202-0880
최은창(Choi, Eun Chang)
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