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Mapping patterns of locoregional recurrence following contemporary treatment with radiation therapy for breast cancer: A multi-institutional validation study of the ESTRO consensus guideline on clinical target volume

 Jee Suk Chang  ;  Jeongshim Lee  ;  Mison Chun  ;  Kyung Hwan Shin  ;  Won Park  ;  Jong Hoon Lee  ;  Jin Hee Kim  ;  Won Sup Yoon  ;  Ik Jae Lee  ;  Juree Kim  ;  Hye Li Park  ;  Yong Bae Kim 
 RADIOTHERAPY AND ONCOLOGY, Vol.126(1) : 139-147, 2018 
Journal Title
Issue Date
Aged ; Breast Neoplasms/pathology ; Breast Neoplasms/radiotherapy* ; Breast Neoplasms/surgery ; Consensus ; Female ; Humans ; Lymph Nodes/pathology ; Mastectomy ; Middle Aged ; Neoplasm Recurrence, Local/pathology ; Radiotherapy Planning, Computer-Assisted/methods* ; Radiotherapy Planning, Computer-Assisted/standards* ; Radiotherapy, Conformal/methods ; Tomography, X-Ray Computed/methods
Breast cancer recurrence ; Clinical target volume ; Radiation therapy ; Recurrence patterns
BACKGROUND AND PURPOSE: To validate the ESTRO guideline on clinical target volume (CTV) delineation for breast cancer using a multi-centre dataset. MATERIALS AND METHODS: Patients with axial imaging of gross locoregional recurrence (LRR) were identified from 10 participating institutions. All patients received RT, albeit not to all regional node. The location of LRR was transferred to the corresponding area on representative axial computed tomography images and compared with ESTRO-CTV. RESULTS: The locations of LRRs in 234 patients with 337 recurrence lesions were mapped. The ESTRO-CTV encompassed 97.6% of all LRRs, except in lymph node level 4 and the pectoralis muscle. Although 8.8% of level 4 failures occurred outside the ESTRO-CTV, cranial to the subclavian artery, all nodes were located within 6 mm cranially. Another 20% occurred posterolateral to anterior scalene muscles; however, 11/16 cases had simultaneous multiple lymph node recurrences, and 8/16 initially had N2-3 tumours. Local recurrence at the pectoralis muscle was prominent in patients undergoing mastectomy but not breast-conservation surgery (28% vs. 2.9%, P = .001). CONCLUSIONS: Our mapping data demonstrated that the ESTRO-CTV, with some considerations, successfully encompassed most LRRs in patients undergoing contemporary management, thus validating ESTRO-CTV to be valuable for highly conformal radiation therapy techniques.
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1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실) > 1. Journal Papers
Yonsei Authors
Kim, Yong Bae(김용배) ORCID logo https://orcid.org/0000-0001-7573-6862
Lee, Ik Jae(이익재) ORCID logo https://orcid.org/0000-0001-7165-3373
Chang, Jee Suk Paul(장지석) ORCID logo https://orcid.org/0000-0001-7685-3382
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