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Impact of a bladder cuff excision during radical nephroureterectomy on cancer specific survival in patients with upper tract urothelial cancer in Korea: a retrospective, multi-institutional study

Authors
 Yun-Sok HA  ;  Jae-Wook CHUNG  ;  Seock H. CHOI  ;  Jun N. LEE  ;  Bum S. KIM  ;  Tae-Hwan KIM  ;  Eun S. YOO  ;  Tae G. KWON  ;  Seok-Soo BYUN  ;  Young D. CHOI  ;  Ho W. KANG  ;  Seok J. YUN  ;  Wun-Jae KIM  ;  Hyun T. KIM 
Citation
 MINERVA UROLOGICA E NEFROLOGICA, Vol.69(5) : 466-474, 2017 
Journal Title
 MINERVA UROLOGICA E NEFROLOGICA 
ISSN
 0393-2249 
Issue Date
2017
MeSH
Aged ; Aged, 80 and over ; Comorbidity ; Female ; Humans ; Kaplan-Meier Estimate ; Male ; Middle Aged ; Nephrectomy/adverse effects ; Nephrectomy/methods* ; Prognosis ; Republic of Korea/epidemiology ; Retrospective Studies ; Survival Rate ; Ureter/surgery* ; Urinary Bladder/surgery* ; Urologic Neoplasms/mortality* ; Urologic Neoplasms/surgery*
Abstract
BACKGROUND: Radical nephroureterectomy (RNU) with bladder cuff excision (BCE) is the surgical principle adopted for the treatment of upper tract urothelial cancers (UTUCs). However, not all RNUs are performed with BCE. We quantified the prognostic impact of RNU with BCE on cancer-specific survival (CSS) in a large patient population. METHODS: In total, 505 patients with UTUC were enrolled from four different institutions. The clinicopathological parameters of patients who underwent RNU with and without BCE were compared. The Kaplan-Meier and multivariate Cox regression analyses were performed to assess the influence of BCE on CSS. RESULTS: In total, 60 (11.9%) patients had not undergone BCE during RNU. Compared to patients who underwent BCE, these patients were older and had more comorbidities. Patients with UTUC who had not undergone BCE were more likely to be associated with ≥pT3, margin positivity, and renal pelvis localization compared to patients who underwent BCE. Median follow-up periods were 30.5 months (range, 6-144 months). The Kaplan-Meier estimates revealed that BCE during RNU was not significantly associated with CSS in all UTUC patients and in the subgroup with renal pelvis localization; however, patients who underwent RNU without BCE had significantly worse CSS rates compared to patients who underwent RNU with BCE in the subgroup analysis of patients with ureteral cancer. Multivariate analysis identified BCE as an independent prognostic factor of CSS in patients with ureteral cancer. CONCLUSIONS: In the present study, RNU without BCE resulted in significantly worse CSS in ureteral cancer patients, which indicated that BCE should be mandatory in patients with ureteral cancer.
Files in This Item:
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DOI
10.23736/S0393-2249.17.02807-7
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Urology (비뇨의학교실) > 1. Journal Papers
Yonsei Authors
Choi, Young Deuk(최영득) ORCID logo https://orcid.org/0000-0002-8545-5797
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/163800
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