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Effects of locally administered rhBMP-2 and bisphosphonate on bone regeneration in the rat fibula

Authors
 E‐J Kwak  ;  I‐H Cha  ;  W Nam  ;  JI Yook  ;  Y‐B Park  ;  HJ Kim 
Citation
 Oral Diseases, Vol.24(6) : 1042-1056, 2018 
Journal Title
 Oral Diseases 
ISSN
 1354-523X 
Issue Date
2018
Keywords
absorbable collagen sponge ; bisphosphonate ; bone formation ; recombinant human bone morphogenetic protein-2 ; xenogenic bone graft
Abstract
OBJECTIVE: To evaluate the ability of xenogenic bone and absorbable collagen sponge to function as an rhBMP-2 carrier and the osteoinductivity of bisphosphonate by comparison with recombinant human bone morphogenetic protein-2 (rhBMP-2). MATERIALS AND METHODS: Thirty-two Sprague-Dawley male rats were divided into four groups. Segmental ostectomy of both fibulae was performed, and the defect area was then treated with Rapiderm Pad (absorbable collagen sponge; COL_BMP) or CollaOss (xenogenic bone; XENO_BMP) with application of rhBMP-2. Alternatively, both fibulae were grafted with xenogenic bone with different bisphosphonate concentrations (XENO_Low BP, XENO_High BP). After 4 or 8 weeks, animals were sacrificed, and radiographic, histological, histomorphometric, and immunohistochemical analyses were performed. RESULTS: Recombinant human bone morphogenetic protein-2 promoted bone formation, regardless of the carrier, and exhibited continuity between the graft material and defect area. Moreover, the results showed that higher concentrations of bisphosphonate were associated with greater bone formation than lower concentrations of bisphosphonate. CONCLUSION: Absorbable collagen sponges with rhBMP-2 were advantageous in that there was no remaining graft material and that the bone was remodeled to resemble the existing fibula. The local application of bisphosphonate promoted new bone formation, particularly when used at high concentrations. High-concentration bisphosphonate induced new bone formation comparable to rhBMP-2 with lesser remaining bone material.
Full Text
https://onlinelibrary.wiley.com/doi/abs/10.1111/odi.12864
DOI
10.1111/odi.12864
Appears in Collections:
1. Journal Papers (연구논문) > 2. College of Dentistry (치과대학) > Dept. of Oral and Maxillofacial Surgery (구강악안면외과학교실)
1. Journal Papers (연구논문) > 2. College of Dentistry (치과대학) > Dept. of Prosthodontics (보철과학교실)
1. Journal Papers (연구논문) > 2. College of Dentistry (치과대학) > Dept. of Oral Pathology (구강병리학교실)
Yonsei Authors
김형준(Kim, Hyung Jun) ORCID logo https://orcid.org/0000-0001-8247-4004
남웅(Nam, Woong) ORCID logo https://orcid.org/0000-0003-0146-3624
박영범(Park, Young Bum)
육종인(Yook, Jong In) ORCID logo https://orcid.org/0000-0002-7318-6112
차인호(Cha, In Ho) ORCID logo https://orcid.org/0000-0001-8259-2190
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/163775
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