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Systemic inflammation and suicide risk: cohort study of 419 527 Korean men and women

Authors
 G David Batty  ;  Keum Ji Jung  ;  Sunmi Lee  ;  Joung Hwan Back  ;  Sun Ha Jee 
Citation
 Journal of Epidemiology and Community Health, Vol.72(7) : 572-574, 2018 
Journal Title
 Journal of Epidemiology and Community Health 
ISSN
 0143-005X 
Issue Date
2018
Keywords
cohort studies ; epidemiology ; suicide
Abstract
BACKGROUND: Data from only one study have been used to examine the relationship between systemic inflammation and later suicide risk, and a strong positive association was apparent. More research is needed, particularly looking at gender, not least because women are seemingly more vulnerable to inflammation-induced mood changes than men. METHODS: The Korean Cancer Prevention Study had a cohort of over 1 million individuals aged 30-95 years at baseline examination between 1992 and 1995, when white blood cell count, our marker of systemic inflammation, was assessed. RESULTS: A mean of 16.6 years of mortality surveillance gave rise to 1010 deaths from suicide in 106 643 men, and 1019 deaths from suicide in 312 884 women. There was little evidence of an association between our inflammation marker and suicide mortality in men after multiple adjustments. In women, however, those in the second inflammation quartile and higher experienced around 30% increase risk of death (HR 1.35; 95% CI: 1.11-1.64). CONCLUSIONS: Higher levels of systemic inflammation were moderately related to an elevated risk of suicide death in women but not in men.
Files in This Item:
T201803441.pdf Download
DOI
10.1136/jech-2017-210086
Appears in Collections:
4. Graduate School of Public Health (보건대학원) > Graduate School of Public Health (보건대학원) > 1. Journal Papers
Yonsei Authors
Jung, Keum Ji(정금지) ORCID logo https://orcid.org/0000-0003-4993-0666
Jee, Sun Ha(지선하) ORCID logo https://orcid.org/0000-0001-9519-3068
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/163749
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