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High prevalence of Clostridium difficile PCR ribotype 078 in pigs in Korea

Authors
 Ha-Young Kim  ;  Ara Cho  ;  Jong Wan Kim  ;  Heejung Kim  ;  Bumseok Kim 
Citation
 ANAEROBE, Vol.51 : 42-46, 2018 
Journal Title
 ANAEROBE 
ISSN
 1075-9964 
Issue Date
2018
MeSH
Animals ; Bacterial Toxins/genetics ; Carrier State/epidemiology ; Carrier State/microbiology ; Carrier State/veterinary* ; Clostridium difficile/classification* ; Clostridium difficile/genetics ; Clostridium difficile/isolation & purification* ; Diarrhea/epidemiology ; Diarrhea/microbiology ; Diarrhea/veterinary* ; Feces/microbiology ; Genetic Variation* ; Korea/epidemiology ; Polymerase Chain Reaction ; Prevalence ; Ribotyping* ; Swine ; Swine Diseases/epidemiology* ; Swine Diseases/microbiology
Keywords
Clostridium difficile ; Pig ; Ribotype 078 ; Toxin profile
Abstract
Clostridium difficile can cause neonatal enteritis, but has been isolated from both diseased and healthy pigs. C. difficile shedding by pigs is a potential source of zoonotic transmission to humans. The objectives of this study were to characterize the prevalence and genotype of C. difficile with respect to age and health status in the pig industry for the first time in Korea. Fecal samples of 910 pigs were analyzed for the presence of C. difficile. In total, 176 (19.3%) C. difficile strains were isolated. The prevalence was significantly higher (p < 0.01) in diarrheic samples (30.4%) than in non-diarrheic samples (13.3%). The prevalence was highest in diarrheic suckling piglets (53.6%), followed by diarrheic sows (40.0%) and non-diarrheic suckling piglets (34.0%). The toxin genes tcdA, tcdB, cdtA, and cdtB were all detected in 153 isolates (A+B+CDT+, 86.9%). Furthermore, the majority of toxigenic strains (86.5%) were identified as PCR ribotype 078, which is an important pathogen in both pigs and humans. These results indicated that C. difficile is a leading causative pathogen of neonatal diarrhea in piglets in Korea.
Full Text
https://www.sciencedirect.com/science/article/pii/S1075996418300568
DOI
10.1016/j.anaerobe.2018.03.012
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Heejung(김희정) ORCID logo https://orcid.org/0000-0002-0190-703X
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/163725
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