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CTCF is required for maintenance of auditory hair cells and hearing function in the mouse cochlea.

DC FieldValueLanguage
dc.contributor.author김형표-
dc.contributor.author복진웅-
dc.contributor.author신정오-
dc.contributor.author마지현-
dc.date.accessioned2018-10-22T13:17:56Z-
dc.date.available2018-10-22T13:17:56Z-
dc.date.issued2018-
dc.identifier.issn0006-291X-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/163721-
dc.description.abstractAuditory hair cells play an essential role in hearing. These cells convert sound waves, mechanical stimuli, into electrical signals that are conveyed to the brain via spiral ganglion neurons. The hair cells are located in the organ of Corti within the cochlea. They assemble in a special arrangement with three rows of outer hair cells and one row of inner hair cells. The proper differentiation and preservation of auditory hair cells are essential for acquiring and maintaining hearing function, respectively. Many genetic regulatory mechanisms underlying hair-cell differentiation and maintenance have been elucidated to date. However, the role of epigenetic regulation in hair-cell differentiation and maintenance has not been definitively demonstrated. CTCF is an essential epigenetic component that plays a primary role in the organization of global chromatin architecture. To determine the role of CTCF in mammalian hair cells, we specifically deleted Ctcf in developing hair cells by crossing Ctcffl/fl mice with Gfi1Cre/+ mice. Gfi1Cre; Ctcffl/fl mice did not exhibit obvious developmental defects in hair cells until postnatal day 8. However, at 3 weeks, the Ctcf deficiency caused intermittent degeneration of the stereociliary bundles of outer hair cells, resulting in profound hearing impairment. At 5 weeks, most hair cells were degenerated in Gfi1Cre; Ctcffl/fl mice, and defects in other structures of the organ of Corti, such as the tunnel of Corti and Nuel's space, became apparent. These results suggest that CTCF plays an essential role in maintaining hair cells and hearing function in mammalian cochlea.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherElsevier-
dc.relation.isPartOfBIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleCTCF is required for maintenance of auditory hair cells and hearing function in the mouse cochlea.-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Environmental Medical Biology-
dc.contributor.googleauthorJi-Hyun Ma-
dc.contributor.googleauthorHyoung-Pyo Kim-
dc.contributor.googleauthorJinwoong Bok-
dc.contributor.googleauthorJeong-Oh Shin-
dc.identifier.doi10.1016/j.bbrc.2018.08.017-
dc.contributor.localIdA01163-
dc.contributor.localIdA01865-
dc.relation.journalcodeJ00281-
dc.identifier.eissn1090-2104-
dc.identifier.pmid30107916-
dc.identifier.urlhttps://www.sciencedirect.com/science/article/pii/S0006291X18316905-
dc.subject.keywordCCCTC-Binding factor (CTCF)-
dc.subject.keywordHair cell-
dc.subject.keywordHearing loss-
dc.contributor.alternativeNameKim, Hyoung Pyo-
dc.contributor.alternativeNameBok, Jin Woong-
dc.contributor.affiliatedAuthorKim, Hyoung Pyo-
dc.contributor.affiliatedAuthorBok, Jin Woong-
dc.citation.volume503-
dc.citation.number4-
dc.citation.startPage2646-
dc.citation.endPage2652-
dc.identifier.bibliographicCitationBIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Vol.503(4) : 2646-2652, 2018-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Environmental Medical Biology (환경의생물학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Anatomy (해부학교실) > 1. Journal Papers

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