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Proof-of-concept study of vertical augmentation using block-type allogenic bone grafts: A preclinical experimental study on rabbit calvaria

DC Field Value Language
dc.contributor.author이중석-
dc.contributor.author정의원-
dc.contributor.author조규성-
dc.contributor.author최성호-
dc.date.accessioned2018-10-22T13:16:00Z-
dc.date.available2018-10-22T13:16:00Z-
dc.date.issued2018-
dc.identifier.issn1552-4973-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/163679-
dc.description.abstractThis study aimed to quantify the healing following vertical augmentation of allogenic bone blocks with/without recombinant human bone morphogenetic protein-2 (rhBMP-2) on rabbit calvaria. Experiments were performed using allogenic bone blocks which were grafted bilaterally with or without rhBMP-2 on 20 rabbit calvaria, and these animals were divided to four groups according to the use of rhBMP-2 and healing periods (2 and 8 weeks; n = 10 in each group). Onlay-type bone blocks (8 mm in diameter and 5 mm high) were fixed with a self-tapping screw after removing the cortex in the control group, and the same protocol was applied with the addition of soaking the bone blocks with rhBMP-2 for 15 min in the test group. Radiographic and histologic analyses were performed after 2 or 8 weeks to evaluate the volumetric stability and bone regeneration within the grafted area. The radiographic analysis revealed that the height of the allogenic bone block decreased but its volume was maintained from 2 to 8 weeks in both the control and test groups. The histologic results demonstrated a statistically significant increase in new bone area in the test group, especially in the lower region adjacent to the preexisting calvarial floor. The amount of newly formed bone in all regions of the augmented bone blocks in both the control and test groups was greater at 8 weeks than at 2 weeks. In conclusion, the vertically grafted allogenic bone block maintained its volume with new bone formation, and this was accelerated by the addition of rhBMP-2. These findings indicate that allogenic bone block soaked with rhBMP-2 could be a useful candidate biomaterial for vertical augmentation.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherSpringer-
dc.relation.isPartOfJOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleProof-of-concept study of vertical augmentation using block-type allogenic bone grafts: A preclinical experimental study on rabbit calvaria-
dc.typeArticle-
dc.contributor.collegeCollege of Dentistry-
dc.contributor.departmentDept. of Periodontology-
dc.contributor.googleauthorJi‐Sun Lee-
dc.contributor.googleauthorJung‐Seok Lee-
dc.contributor.googleauthorMyung‐Hun Kang-
dc.contributor.googleauthorUi‐Won Jung-
dc.contributor.googleauthorSeong‐Ho Choi-
dc.contributor.googleauthorKyoo‐Sung Cho-
dc.identifier.doi10.1002/jbm.b.34087-
dc.contributor.localIdA03185-
dc.contributor.localIdA03692-
dc.contributor.localIdA03810-
dc.contributor.localIdA04081-
dc.relation.journalcodeJ01267-
dc.identifier.eissn1552-4981-
dc.identifier.pmid30027459-
dc.identifier.urlhttps://onlinelibrary.wiley.com/doi/10.1002/jbm.b.34087-
dc.contributor.alternativeNameLee, Jung Seok-
dc.contributor.alternativeNameJung, Ui Won-
dc.contributor.alternativeNameCho, Kyoo Sung-
dc.contributor.alternativeNameChoi, Seong Ho-
dc.contributor.affiliatedAuthorLee, Jung Seok-
dc.contributor.affiliatedAuthorJung, Ui Won-
dc.contributor.affiliatedAuthorCho, Kyoo Sung-
dc.contributor.affiliatedAuthorChoi, Seong Ho-
dc.citation.volume106-
dc.citation.number7-
dc.citation.startPage2700-
dc.citation.endPage2707-
dc.identifier.bibliographicCitationJOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS, Vol.106(7) : 2700-2707, 2018-
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Periodontics (치주과학교실) > 1. Journal Papers

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