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The efficacy of single-dose postoperative intravenous dexamethasone for pain relief after endoscopic submucosal dissection for gastric neoplasm

DC Field Value Language
dc.contributor.author이혜원-
dc.contributor.author이혁-
dc.contributor.author정현수-
dc.contributor.author박준철-
dc.contributor.author신성관-
dc.contributor.author이상길-
dc.contributor.author홍정화-
dc.contributor.author김동욱-
dc.date.accessioned2018-10-16T16:40:24Z-
dc.date.available2018-10-16T16:40:24Z-
dc.date.issued2014-
dc.identifier.issn0930-2794-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/163608-
dc.description.abstractBACKGROUND: Endoscopic submucosal dissection (ESD) is the gold standard technique for en bloc resection of large superficial tumors in the upper and lower gastrointestinal tract. Little is known about the management of epigastric pain after ESD of gastric neoplasms. This study investigated the utility and safety of single-dose, perioperative, intravenous dexamethasone for epigastric pain relief following ESD. METHODS: The efficacy of intravenous dexamethasone 0.15 mg/kg (DEXA group) compared with saline-only placebo (placebo) for epigastric pain after ESD of early gastric neoplasms was assessed in a double-blinded, placebo-controlled trial. Patients completed a questionnaire about present pain intensity (PPI) and short-form McGill pain (SF-MP) categories for immediate and 6-, 12-, and 24-h postoperative periods. The primary outcome variable was PPI at 6 h following ESD. Secondary outcome variables included pain medication, SF-MP scores, complications, second-look endoscopic findings, and length of stay. RESULTS: A total of 36 patients participated in the study. The mean 6-h PPI value was lower (p < 0.001) in the DEXA group (1.61 ± 0.21) than in the placebo group (2.66 ± 0.19). The total 6-h SF-MP score, especially the sensory domain, was higher (p = 0.054) in the placebo group (11.56 ± 0.75) than in the DEXA group (8.89 ± 0.75). Tramadol for epigastric pain relief was more frequent (p = 0.026) in the placebo group (44.4%) than in the DEXA group (11.1%). No differences were noted between groups in length of stay or complications, including acute or delayed bleeding. The distribution of artificial ulcer patterns at 48-h post-ESD as determined by second-look endoscopy was similar in both groups. CONCLUSION: Single-dose perioperative intravenous dexamethasone after ESD effectively relieved epigastric pain 6 h postoperatively.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherSpringer-
dc.relation.isPartOfSURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdenocarcinoma/pathology-
dc.subject.MESHAdenocarcinoma/surgery-
dc.subject.MESHAdenoma/pathology-
dc.subject.MESHAdenoma/surgery-
dc.subject.MESHDexamethasone/administration & dosage*-
dc.subject.MESHDose-Response Relationship, Drug-
dc.subject.MESHDouble-Blind Method-
dc.subject.MESHFemale-
dc.subject.MESHGastric Mucosa/surgery*-
dc.subject.MESHGastroscopy*-
dc.subject.MESHGlucocorticoids/administration & dosage*-
dc.subject.MESHHumans-
dc.subject.MESHInjections, Intravenous-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHMultivariate Analysis-
dc.subject.MESHPain Measurement-
dc.subject.MESHPain, Postoperative/prevention & control*-
dc.subject.MESHStomach Neoplasms/pathology-
dc.subject.MESHStomach Neoplasms/surgery*-
dc.titleThe efficacy of single-dose postoperative intravenous dexamethasone for pain relief after endoscopic submucosal dissection for gastric neoplasm-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Internal Medicine-
dc.contributor.googleauthorHye Won Lee-
dc.contributor.googleauthorHyuk Lee-
dc.contributor.googleauthorHyunsoo Chung-
dc.contributor.googleauthorJun Chul Park-
dc.contributor.googleauthorSung Kwan Shin-
dc.contributor.googleauthorSang Kil Lee-
dc.contributor.googleauthorYoung Chan Lee-
dc.contributor.googleauthorJung Hwa Hong-
dc.contributor.googleauthorDong Wook Kim-
dc.identifier.doi10.1007/s00464-014-3463-4-
dc.contributor.localIdA03318-
dc.contributor.localIdA03285-
dc.contributor.localIdA03765-
dc.contributor.localIdA01676-
dc.contributor.localIdA02112-
dc.contributor.localIdA02812-
dc.contributor.localIdA04433-
dc.contributor.localIdA00407-
dc.relation.journalcodeJ02703-
dc.identifier.eissn1432-2218-
dc.identifier.pmid24570015-
dc.identifier.urlhttps://link.springer.com/article/10.1007%2Fs00464-014-3463-4-
dc.subject.keywordEndoscopic submucosal dissection-
dc.subject.keywordEarly gastric cancer-
dc.subject.keywordPain relief-
dc.subject.keywordIntravenous dexamethasone-
dc.subject.keywordPresent pain intensity-
dc.contributor.alternativeNameLee, Hye Won-
dc.contributor.alternativeNameLee, Hyuk-
dc.contributor.alternativeNameChung, Hyun Soo-
dc.contributor.alternativeNamePark, Jun Chul-
dc.contributor.alternativeNameShin, Sung Kwan-
dc.contributor.alternativeNameLee, Sang Kil-
dc.contributor.alternativeNameHong, Jung Hwa-
dc.contributor.alternativeNameKim, Dong Wook-
dc.contributor.affiliatedAuthorLee, Hye Won-
dc.contributor.affiliatedAuthorLee, Hyuk-
dc.contributor.affiliatedAuthorChung, Hyun Soo-
dc.contributor.affiliatedAuthorPark, Jun Chul-
dc.contributor.affiliatedAuthorShin, Sung Kwan-
dc.contributor.affiliatedAuthorLee, Sang Kil-
dc.contributor.affiliatedAuthorHong, Jung Hwa-
dc.contributor.affiliatedAuthorKim, Dong Wook-
dc.citation.volume28-
dc.citation.number8-
dc.citation.startPage2334-
dc.citation.endPage2341-
dc.identifier.bibliographicCitationSURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES, Vol.28(8) : 2334-2341, 2014-
dc.identifier.rimsid60533-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers

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