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The clinical implication of the number of lymph nodes harvested during sentinel lymph node biopsy and its effects on survival outcome in patients with node-negative breast cancer

Authors
 Mi Kyoung Kim  ;  Hyung Seok Park  ;  Jee Ye Kim  ;  Sanghwa Kim  ;  Sanggeun Nam  ;  Seho Park  ;  Seung Il Kim 
Citation
 American Journal of Surgery, Vol.214(4) : 726-732, 2017 
Journal Title
 American Journal of Surgery 
ISSN
 0002-9610 
Issue Date
2017
MeSH
Axilla ; Breast Neoplasms/pathology* ; Breast Neoplasms/therapy ; Female ; Humans ; Immunohistochemistry ; Lymph Node Excision* ; Lymphatic Metastasis/pathology* ; Middle Aged ; Neoplasm Invasiveness/pathology ; Neoplasm Staging ; Prognosis ; Sentinel Lymph Node Biopsy/methods* ; Survival Rate
Keywords
Breast ; Neoplasms ; Optimal number ; Prognosis ; Sentinel lymph node biopsy ; Survival
Abstract
BACKGROUND: The optimal number of sentinel lymph nodes (SLN) that need to be harvested to achieve favorable survival outcome during a SLN biopsy (SLNB) has not yet been established. METHODS: Six hundred and thirteen patients with clinically node-negative breast cancer who underwent SLNB were reviewed. Survival outcomes according to the number of total harvested lymph nodes (THLNs), defined as the sum of enumerated SLNs and non-SLNs were analyzed. RESULTS: Patients with only 1 THLN showed lower recurrence-free survival (RFS) as compared to those with ≥2 THLNs (p = 0.049). In multivariate analysis, only 1 THLN was associated with poor RFS (HR = 2.711; p = 0.029). CONCLUSIONS: Removing at least 2 lymph nodes during SLNB may be acceptable. Harvesting only 1 lymph node should be undertaken cautiously because of false negative results and increasing the subsequent recurrence rate.
Full Text
https://www.sciencedirect.com/science/article/pii/S0002961016309540
DOI
10.1016/j.amjsurg.2016.10.019
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Sang Hwa(김상화)
Kim, Seung Il(김승일)
Kim, Jee Ye(김지예) ORCID logo https://orcid.org/0000-0003-3936-4410
Nam, Sanggeun(남상근)
Park, Se Ho(박세호) ORCID logo https://orcid.org/0000-0001-8089-2755
Park, Hyung Seok(박형석) ORCID logo https://orcid.org/0000-0001-5322-6036
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/163604
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