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Anesthetics Mechanisms: A Review of Putative Target Proteins at the Cellular and Molecular Level.

Authors
 Danuh Kim  ;  Hyun Joo Kim  ;  Seunghyun Ahn 
Citation
 Current Drug Targets, Vol.19(11) : 1333-1343, 2018 
Journal Title
 Current Drug Targets 
Issue Date
2018
Keywords
Anesthetics ; CAMkinase ; G-protein coupled receptor ; SIRT2 deacetylase ; cytoskeleton ; integrin ; ligand-gated ion channel ; target protein
Abstract
Despite widespread clinical use of anesthetics, the exact mechanisms of anesthetic action are unclear. In terms of physiological action, a broad mechanism of general anesthesia including perturbations of neurotransmission has been suggested. However, the mechanism of anesthetic action at the molecular level is less clear. Specifically, how anesthetics affect neurons and glial cells and which proteins they interact with remains to be explored. Several recent studies have investigated the molecular interactions between proteins and anesthetics. In this review, we summarize the molecular mechanisms of anesthetic action in the intracellular signaling pathways of neuronal and glial cells.
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/163537
DOI
10.2174/1389450119666180502112029
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실)
Yonsei Authors
김현주(Kim, Hyun Joo) ORCID logo https://orcid.org/0000-0003-1963-8955
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