Cited 10 times in
Whole Exome Sequencing Identifies a Novel Hedgehog-Interacting Protein G516R Mutation in Locally Advanced Papillary Thyroid Cancer
DC Field | Value | Language |
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dc.contributor.author | 김다함 | - |
dc.contributor.author | 이잔디 | - |
dc.contributor.author | 정선향 | - |
dc.contributor.author | 조영석 | - |
dc.contributor.author | 이슬기 | - |
dc.contributor.author | 이우경 | - |
dc.contributor.author | 임승혁 | - |
dc.date.accessioned | 2018-10-11T08:59:02Z | - |
dc.date.available | 2018-10-11T08:59:02Z | - |
dc.date.issued | 2018 | - |
dc.identifier.issn | 1661-6596 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/163533 | - |
dc.description.abstract | Locally advanced thyroid cancer exhibits aggressive clinical features requiring extensive neck dissection. Therefore, it is important to identify changes in the tumor biology before local progression. Here, whole exome sequencing (WES) using tissues from locally advanced papillary thyroid cancer (PTC) presented a large number of single nucleotide variants (SNVs) in the metastatic lymph node (MLN), but not in normal tissues and primary tumors. Among those MLN-specific SNVs, a novel HHIP G516R (G1546A) mutation was also observed. Interestingly, in-depth analysis for exome sequencing data from the primary tumor presented altered nucleotide 'A' at a very low frequency indicating intra-tumor heterogeneity between the primary tumor and MLN. Computational prediction models such as PROVEAN and Polyphen suggested that HHIP G516R might affect protein function and stability. In vitro, HHIP G516R increased cell proliferation and promoted cell migration in thyroid cancer cells. HHIP G516R, a missense mutation, could be a representative example for the intra-tumor heterogeneity of locally advanced thyroid cancer, which can be a potential future therapeutic target for this disease. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.language | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | - |
dc.publisher | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Whole Exome Sequencing Identifies a Novel Hedgehog-Interacting Protein G516R Mutation in Locally Advanced Papillary Thyroid Cancer | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Internal Medicine | - |
dc.contributor.googleauthor | Woo Kyung Lee | - |
dc.contributor.googleauthor | Seul Gi Lee | - |
dc.contributor.googleauthor | Seung Hyuk Yim | - |
dc.contributor.googleauthor | Daham Kim | - |
dc.contributor.googleauthor | Hyunji Kim | - |
dc.contributor.googleauthor | Seonhyang Jeong | - |
dc.contributor.googleauthor | Sang Geun Jung | - |
dc.contributor.googleauthor | Young Suk Jo | - |
dc.contributor.googleauthor | Jandee Lee | - |
dc.identifier.doi | 10.3390/ijms19102867 | - |
dc.contributor.localId | A00363 | - |
dc.contributor.localId | A03066 | - |
dc.contributor.localId | A03621 | - |
dc.contributor.localId | A03853 | - |
dc.contributor.localId | A02991 | - |
dc.relation.journalcode | J01133 | - |
dc.identifier.eissn | 1422-0067 | - |
dc.identifier.pmid | 30241415 | - |
dc.subject.keyword | hedgehog proteins | - |
dc.subject.keyword | neoplasm invasiveness | - |
dc.subject.keyword | thyroid cancer | - |
dc.contributor.alternativeName | Kim, Da Ham | - |
dc.contributor.alternativeName | Lee, Jan Dee | - |
dc.contributor.alternativeName | Jeong, Seon Hyang | - |
dc.contributor.alternativeName | Jo, Young Suk | - |
dc.contributor.affiliatedAuthor | Kim, Da Ham | - |
dc.contributor.affiliatedAuthor | Lee, Jan Dee | - |
dc.contributor.affiliatedAuthor | Jeong, Seon Hyang | - |
dc.contributor.affiliatedAuthor | Jo, Young Suk | - |
dc.citation.volume | 19 | - |
dc.citation.number | 10 | - |
dc.citation.startPage | 2867 | - |
dc.citation.endPage | 2877 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, Vol.19(10) : 2867-2877, 2018 | - |
dc.identifier.rimsid | 60480 | - |
dc.type.rims | ART | - |
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