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Dishevelling Wnt and Hippo

Authors
 Nam Hee Kim  ;  Yoonmi Lee  ;  Jong In Yook 
Citation
 BMB Reports, Vol.51(9) : 425-426, 2018 
Journal Title
 BMB Reports 
ISSN
 1976-6696 
Issue Date
2018
Keywords
Dishevelled ; Hippo pathway ; Tumor suppressor ; Wntsignaling ; YAP
Abstract
As highly conserved signaling cascades of multicellular organisms, Wnt and Hippo pathways control a wide range of cellular activities, including cell adhesion, fate determination, cell cycle, motility, polarity, and metabolism. Dysregulation of those pathways are implicated in many human diseases, including cancer. Similarly to -catenin in the Wnt pathway, the YAP transcription co-activator is a major player in Hippo. Although the intracellular dynamics of YAP are well-known to largely depend on phosphorylation by LATS and AMPK kinases, the molecular effector of YAP cytosolic translocation remains unidentified. Recently, we reported that the Dishevelled (DVL), a key scaffolding protein between canonical and non-canonical Wnt pathway, is responsible for nuclear export of phosphorylated YAP. The DVL is also required for YAP intracellular trafficking induced by E-cadherin, -catenin, or metabolic stress. Note that the p53/LATS2 and LKB1/AMPK tumor suppressor axes, commonly inactivated in human cancer, govern the reciprocal inhibition between DVL and YAP. Conversely, loss of the tumor suppressor allows co-activation of YAP and Wnt independent of epithelial polarity or contact inhibition in human cancer. These observations provide novel mechanistic insight into (1) a tight molecular connection merging the Wnt and Hippo pathways, and (2) the importance of tumor suppressor contexts with respect to controlled proliferation and epithelial polarity regulated by cell adhesion. [BMB Reports: Perspective 2018; 51(9): 425-426]
Files in This Item:
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DOI
10.5483/BMBRep.2018.51.9.179
Appears in Collections:
1. Journal Papers (연구논문) > 5. Research Institutes (연구소) > Oral Cancer Research Institute (구강종양연구소)
1. Journal Papers (연구논문) > 2. College of Dentistry (치과대학) > Dept. of Oral Pathology (구강병리학교실)
Yonsei Authors
김남희(Kim, Nam Hee) ORCID logo https://orcid.org/0000-0002-3087-5276
육종인(Yook, Jong In) ORCID logo https://orcid.org/0000-0002-7318-6112
이윤미(Lee, Yoon Mi)
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/163520
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