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Aberrant Neural Activation Underlying Idiom Comprehension in Korean Children with High Functioning Autism Spectrum Disorder

Authors
 Namwook Kim  ;  Uk-Su Choi  ;  Sungji Ha  ;  Seul Bee Lee  ;  Seung Ha Song  ;  Dong Ho Song  ;  Keun-Ah Cheon 
Citation
 Yonsei Medical Journal, Vol.59(7) : 897-903, 2018 
Journal Title
 Yonsei Medical Journal 
ISSN
 0513-5796 
Issue Date
2018
MeSH
Autism Spectrum Disorder/diagnosis* ; Autism Spectrum Disorder/physiopathology ; Autism Spectrum Disorder/psychology* ; Brain Mapping/methods ; Case-Control Studies ; Child ; Child Development ; Comprehension* ; Female ; Humans ; Language* ; Language Development Disorders/diagnosis* ; Language Development Disorders/psychology ; Language Disorders/psychology* ; Language Tests/standards* ; Magnetic Resonance Imaging/methods* ; Male
Keywords
Autism spectrum disorder ; Korean Autism Social Language Task ; fMRI ; idiom comprehension ; pragmatics
Abstract
PURPOSE: Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by social communication impairments and repetitive behaviors or restricted interests. Impaired pragmatic language comprehension is a universal feature in individuals with ASD. However, the underlying neural basis of pragmatic language is poorly understood. In the present study, we examined neural activation patterns associated with impaired pragmatic language comprehension in ASD, compared to typically developing children (TDC). MATERIALS AND METHODS: Functional magnetic resonance imaging (fMRI) was applied to 15 children with ASD and 18 TDC using the Korean pragmatic language task. RESULTS: Children with ASD were less accurate than TDC at comprehending idioms, particularly when they were required to interpret idioms with mismatched images (mismatched condition). Children with ASD also showed different patterns of neural activity than TDC in all three conditions (neutral, matched, and mismatched). Specifically, children with ASD showed decreased activation in the right inferior frontal gyrus (IFG) (Brodmann area 47) in the mismatched condition, compared with TDC (IFG; t(31)=3.17, p<0.001). CONCLUSION: These results suggest that children with ASD face difficulties in comprehending pragmatic expressions and apply different pragmatic language processes at the neural level.
Files in This Item:
T201802945.pdf Download
DOI
10.3349/ymj.2018.59.7.897
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers
Yonsei Authors
Song, Dong Ho(송동호) ORCID logo https://orcid.org/0000-0002-9647-3130
Cheon, Keun Ah(천근아) ORCID logo https://orcid.org/0000-0001-7113-9286
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/163503
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