Cited 16 times in
Total serum bilirubin and 8-year incident type 2 diabetes mellitus: The Korean Genome and Epidemiology Study
DC Field | Value | Language |
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dc.contributor.author | 권유진 | - |
dc.contributor.author | 박병진 | - |
dc.contributor.author | 이용제 | - |
dc.contributor.author | 정동혁 | - |
dc.date.accessioned | 2018-10-11T08:56:27Z | - |
dc.date.available | 2018-10-11T08:56:27Z | - |
dc.date.issued | 2018 | - |
dc.identifier.issn | 1262-3636 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/163485 | - |
dc.description.abstract | AIM: In this study, the impact of serum bilirubin on new-onset type 2 diabetes mellitus (T2DM) in Korean adults was investigated. METHODS: Data were obtained from the Korean Genome and Epidemiology Study (KoGES), a population-based prospective cohort study. The study enrolled 8650 adults (4015 men and 4635 women), aged 40 to 69 years, who underwent a mean follow-up of 8.4 years. The study population was divided into quartiles (Q) of serum bilirubin levels, with cut-off points at 0.46, 0.61 and 0.82mg/dL for men, and 0.35, 0.47 and 0.61mg/dL for women. T2DM was defined based on the following data: fasting blood glucose≥7.0mmol/L, HbA1c level≥6.5% or 2-h plasma glucose≥11.1mmol/L during a 75-g oral glucose tolerance test. RESULTS: Over the mean 8.4-year follow-up, 786 participants (9.1%) developed T2DM. Compared with Q1, the odds ratios (ORs) and 95% confidence intervals (CIs) for T2DM incidence were 0.52 (0.36-0.74) in men and 0.56 (0.38-0.83) in women aged ≥50 years, respectively, in the highest Q group after adjusting for possible confounding factors. These significant results persisted in those with impaired glucose tolerance and impaired fasting glucose. CONCLUSION: The results of this study reveal a protective role for serum total bilirubin on new-onset T2DM in Korean men and women. In addition, serum total bilirubin had favourable effects on new-onset T2DM in those with impaired glucose tolerance and impaired fasting glucose. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English, French | - |
dc.publisher | Masson | - |
dc.relation.isPartOf | DIABETES & METABOLISM | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Total serum bilirubin and 8-year incident type 2 diabetes mellitus: The Korean Genome and Epidemiology Study | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Family Medicine | - |
dc.contributor.googleauthor | Y.-J. Kwon | - |
dc.contributor.googleauthor | Y.-J. Lee | - |
dc.contributor.googleauthor | B.-J. Park | - |
dc.contributor.googleauthor | K.-W. Hong | - |
dc.contributor.googleauthor | D.-H. Jung | - |
dc.identifier.doi | 10.1016/j.diabet.2017.07.004 | - |
dc.contributor.localId | A04882 | - |
dc.contributor.localId | A01477 | - |
dc.contributor.localId | A02982 | - |
dc.contributor.localId | A03595 | - |
dc.relation.journalcode | J00719 | - |
dc.identifier.eissn | 1878-1780 | - |
dc.identifier.pmid | 28838743 | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S1262363617304779 | - |
dc.subject.keyword | Bilirubin | - |
dc.subject.keyword | Impaired fasting glucose | - |
dc.subject.keyword | Impaired glucose tolerance | - |
dc.subject.keyword | KoGES | - |
dc.subject.keyword | Type 2 diabetes mellitus | - |
dc.contributor.alternativeName | Kwon, Yu-Jin | - |
dc.contributor.alternativeName | Park, Byoung Jin | - |
dc.contributor.alternativeName | Lee, Yong Jae | - |
dc.contributor.alternativeName | Jung, Dong Hyuk | - |
dc.contributor.affiliatedAuthor | Kwon, Yu-Jin | - |
dc.contributor.affiliatedAuthor | Park, Byoung Jin | - |
dc.contributor.affiliatedAuthor | Lee, Yong Jae | - |
dc.contributor.affiliatedAuthor | Jung, Dong Hyuk | - |
dc.citation.volume | 44 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 346 | - |
dc.citation.endPage | 353 | - |
dc.identifier.bibliographicCitation | DIABETES & METABOLISM, Vol.44(4) : 346-353, 2018 | - |
dc.identifier.rimsid | 60434 | - |
dc.type.rims | ART | - |
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