Cited 22 times in
Apoptosis Signal-regulating Kinase 1 Silencing on Astroglial Inflammasomes in an Experimental Model of Ischemic Stroke
DC Field | Value | Language |
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dc.contributor.author | 구본녀 | - |
dc.contributor.author | 김소연 | - |
dc.contributor.author | 김은정 | - |
dc.contributor.author | 김정민 | - |
dc.contributor.author | 박종광 | - |
dc.contributor.author | 전소영 | - |
dc.date.accessioned | 2018-10-11T08:55:21Z | - |
dc.date.available | 2018-10-11T08:55:21Z | - |
dc.date.issued | 2018 | - |
dc.identifier.issn | 0306-4522 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/163468 | - |
dc.description.abstract | Activation of the inflammasome complex contributes to the inflammatory response and cell death under pathologic conditions. The nucleotide-binding oligomerization domain-like receptor pyrin domain-containing 2 (NLRP2) inflammasome is activated in astrocytes after cerebral ischemia, which can aggravate ischemic damage. Apoptosis signal-regulating kinase 1 (ASK1) is an early activator and immune-regulator after ischemic injury, that can lead to cell death. The objective of the present study was to evaluate the role of ASK1 in controlling NLRP2 inflammasomes in astrocytes after cerebral ischemia. In a mouse model of ischemic stroke, the levels of NLRP2 inflammasome components, and interleukin (IL)-1β and IL-18, were quantified in different brain regions. In addition, an astrocyte cell line was subjected to oxygen-glucose deprivation and reperfusion (OGD/R) injury, and the levels of NLRP2 inflammasome factors, IL-1β and IL-18 were evaluated. Ischemic brain injury activated astrocytes. The levels of NLRP2 inflammasome components, IL-1β and IL-18 productions, and cell death increased in the cortex and striatum after ischemic injury. In cultured astrocytes, NLRP2 inflammasome components, IL-1β and IL-18 levels were upregulated after OGD/R. ASK1 silencing or inhibition efficiently reduced NLRP2 inflammasome components and pro-inflammatory cytokine levels in mice and cultured astrocytes. Our findings identify a key role for ASK1 in regulating astroglial inflammasomes after cerebral ischemia. We suggest ASK1 as one of the main targets for astroglial inflammasomes in ischemic stroke. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Elsevier Science | - |
dc.relation.isPartOf | NEUROSCIENCE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Apoptosis Signal-regulating Kinase 1 Silencing on Astroglial Inflammasomes in an Experimental Model of Ischemic Stroke | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Anesthesiology and Pain Medicine | - |
dc.contributor.googleauthor | So Yeong Cheon | - |
dc.contributor.googleauthor | Eun Jung Kim | - |
dc.contributor.googleauthor | So Yeon Kim | - |
dc.contributor.googleauthor | Jeong Min Kim | - |
dc.contributor.googleauthor | Eun Hee Kam | - |
dc.contributor.googleauthor | Jong-Kwang Park | - |
dc.contributor.googleauthor | Bon-Nyeo Koo | - |
dc.identifier.doi | 10.1016/j.neuroscience.2018.08.020 | - |
dc.contributor.localId | A00193 | - |
dc.contributor.localId | A00616 | - |
dc.contributor.localId | A00816 | - |
dc.contributor.localId | A00884 | - |
dc.contributor.localId | A05567 | - |
dc.contributor.localId | A03522 | - |
dc.relation.journalcode | J02362 | - |
dc.identifier.eissn | 1873-7544 | - |
dc.identifier.pmid | 30172704 | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0306452218305657 | - |
dc.subject.keyword | apoptosis signal-regulating kinase 1 | - |
dc.subject.keyword | astrocyte | - |
dc.subject.keyword | inflammasomes | - |
dc.subject.keyword | inflammatory response | - |
dc.subject.keyword | ischemic stroke | - |
dc.contributor.alternativeName | Ku, Bon Nyo | - |
dc.contributor.alternativeName | Kim, So Yeon | - |
dc.contributor.alternativeName | Kim, Eun Jung | - |
dc.contributor.alternativeName | Kim, Jeongmin | - |
dc.contributor.alternativeName | Park, Jong-Kwang | - |
dc.contributor.alternativeName | Cheon, So Yeong | - |
dc.contributor.affiliatedAuthor | Ku, Bon Nyo | - |
dc.contributor.affiliatedAuthor | Kim, So Yeon | - |
dc.contributor.affiliatedAuthor | Kim, Eun Jung | - |
dc.contributor.affiliatedAuthor | Kim, Jeongmin | - |
dc.contributor.affiliatedAuthor | Park, Jong-Kwang | - |
dc.contributor.affiliatedAuthor | Cheon, So Yeong | - |
dc.citation.volume | 390 | - |
dc.citation.startPage | 218 | - |
dc.citation.endPage | 230 | - |
dc.identifier.bibliographicCitation | NEUROSCIENCE, Vol.390 : 218-230, 2018 | - |
dc.identifier.rimsid | 60417 | - |
dc.type.rims | ART | - |
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