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Abnormal lymphatic vessel development is associated with decreased decidual regulatory T cells in severe preeclampsia.

DC FieldValueLanguage
dc.contributor.author권자영-
dc.contributor.author김영한-
dc.contributor.author김유나-
dc.contributor.author김현수-
dc.contributor.author맹용선-
dc.contributor.author박예진-
dc.contributor.author이준호-
dc.contributor.author정윤지-
dc.date.accessioned2018-10-11T08:55:13Z-
dc.date.available2018-10-11T08:55:13Z-
dc.date.issued2018-
dc.identifier.issn1046-7408-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/163467-
dc.description.abstractPROBLEM: The lymphatic vasculature controls leukocytes trafficking and limits the adaptive immune response. In previous models of preeclampsia (PE), defective immune function caused by disruption of lymphangiogenesis was shown to be involved in the disease pathophysiology. Especially, the dysfunction of regulatory T cells (Treg) at the maternal-fetal interface may be one of the causes of severe PE. In particular, activation of Tregs to obtain immune tolerance requires adequate antigen presentation through the lymphatic system. We hypothesized that impaired lymphangiogenesis and imbalanced Tregs at the maternal-fetal interface are associated with the pathophysiology of severe PE. However, the current research addressing this hypothesis is limited. Therefore, to compare differences in lymphangiogenesis in severe PE and normal conditions, we aimed to examine the location of lymphatics at the maternal-fetal interface and to investigate the association between lymphangiogenesis and Tregs in severe PE. METHOD OF STUDY: We obtained entire uterus from normal pregnant mice. Placental and fetal membranes, including decidua, were obtained from 10 pregnant women with severe PE and 10 gestational age-matched controls. Immunohistochemistry for LYVE1 was used to localize the distribution of lymphatic vessels and CD4, CD25, and FOXP3 for Treg. RESULTS: LYVE1-positive vessels were present in the uterine wall of mice. LYVE1-positive lymphatic vessels were localized on the human decidua. Tubular lymphatics were abundant in the control decidua, but significantly reduced in severe PE. Furthermore, lymphatic vessel density correlated with the number of decidual Tregs. CONCLUSION: Abnormal decidual lymphangiogenesis is associated with reduced numbers of decidual Tregs in severe PE.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherWiley-Blackwell-
dc.relation.isPartOfAMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleAbnormal lymphatic vessel development is associated with decreased decidual regulatory T cells in severe preeclampsia.-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Obstetrics & Gynecology-
dc.contributor.googleauthorYun Ji Jung-
dc.contributor.googleauthorYejin Park-
dc.contributor.googleauthorHyun‐Soo Kim-
dc.contributor.googleauthorHwa Jin Lee-
dc.contributor.googleauthorYoo‐Na Kim-
dc.contributor.googleauthorJoonHo Lee-
dc.contributor.googleauthorYoung‐Han Kim-
dc.contributor.googleauthorYong‐Sun Maeng-
dc.contributor.googleauthorJa‐Young Kwon-
dc.identifier.doi10.1111/aji.12970-
dc.contributor.localIdA00246-
dc.contributor.localIdA00730-
dc.contributor.localIdA05561-
dc.contributor.localIdA01114-
dc.contributor.localIdA01346-
dc.contributor.localIdA04836-
dc.contributor.localIdA04846-
dc.contributor.localIdA04797-
dc.relation.journalcodeJ00111-
dc.identifier.eissn1600-0897-
dc.identifier.pmid29756666-
dc.subject.keyworddecidua-
dc.subject.keywordlymphangiogenesis-
dc.subject.keywordregulatory T cell-
dc.subject.keywordsevere preeclampsia-
dc.contributor.alternativeNameKwon, Ja Young-
dc.contributor.alternativeNameKim, Young Han-
dc.contributor.alternativeNameKim, Yoo‐Na-
dc.contributor.alternativeNameKim, Hyun-Soo-
dc.contributor.alternativeNameMaeng, Yong Sun-
dc.contributor.alternativeNamePark, Yejin-
dc.contributor.alternativeNameLee, Joon Ho-
dc.contributor.alternativeNameJung, Yun Ji-
dc.contributor.affiliatedAuthorKwon, Ja Young-
dc.contributor.affiliatedAuthorKim, Young Han-
dc.contributor.affiliatedAuthorKim, Yoo‐Na-
dc.contributor.affiliatedAuthorKim, Hyun-Soo-
dc.contributor.affiliatedAuthorMaeng, Yong Sun-
dc.contributor.affiliatedAuthorPark, Yejin-
dc.contributor.affiliatedAuthorLee, Joon Ho-
dc.contributor.affiliatedAuthorJung, Yun Ji-
dc.citation.volume80-
dc.citation.number1-
dc.citation.startPagee12970-
dc.identifier.bibliographicCitationAMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY, Vol.80(1) : e12970, 2018-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Obstetrics and Gynecology (산부인과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
5. Research Institutes (연구소) > Corneal Dystrophy Research Institute (각막이상증연구소) > 1. Journal Papers

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