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Impact of optimal glycemic control on the progression of coronary artery calcification in asymptomatic patients with diabetes.

DC FieldValueLanguage
dc.contributor.author성지민-
dc.contributor.author이지현-
dc.contributor.author장혁재-
dc.contributor.author한동희-
dc.date.accessioned2018-10-11T08:53:00Z-
dc.date.available2018-10-11T08:53:00Z-
dc.date.issued2018-
dc.identifier.issn0167-5273-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/163426-
dc.description.abstractBACKGROUND: Data on the impact of optimal glycemic control (OGC) on the progression of coronary artery calcification, an important marker for future adverse cardiovascular events in individuals with diabetes are limited. METHODS: We investigated 1637 asymptomatic adults with diabetes (56 ± 8 years, 88.8% men) and no history of coronary artery disease or stroke, who underwent serial coronary artery calcium (CAC) screening. The median inter-scan period was 3.0 (2.0-4.4) years. The change in CAC was compared base on OGC status. OGC was defined as a follow-up hemoglobin A1C (HbA1C) of <7.0%, and CAC progression was defined by a square root (√) transformed difference between the baseline and follow-up CAC scores (Δ √transformed CAC) of ≥2.5. RESULTS: Despite no significant difference in the baseline CAC scores, the incidence of CAC progression was lower in the OGC group than in the non-OGC group (45.4% vs. 51.7%; p < 0.013). The two groups differed in the Δ √transformed (OGC, 3.8 ± 6.4; non-OGC, 4.7 ± 6.9; p = 0.016) and annualized Δ √transformed CAC (OGC, 1.1 ± 2.4; non-OGC, 1.4 ± 2.6; p = 0.010) scores. Subgroup analysis showed that OGC significantly reduced the risk of CAC progression in patients aged <65 years and in: smokers, and patients with a body mass index of <25 kg/m2, dyslipidemia, and baseline CAC scores between 1-100 and >400. In multivariate regression analysis, OGC was independently associated with a reduced risk of CAC progression (odds ratio, 0.745, 95% confidence interval, 0.601-0.924; p = 0.007). CONCLUSION: OGC attenuated the progression of coronary artery calcification in asymptomatic patients with diabetes.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherElsevier-
dc.relation.isPartOfInternational Journal of Cardiology-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleImpact of optimal glycemic control on the progression of coronary artery calcification in asymptomatic patients with diabetes.-
dc.typeArticle-
dc.contributor.collegeResearch Institutes-
dc.contributor.departmentYonsei Cardiovascular Research Institute-
dc.contributor.googleauthorKi-Bum Won-
dc.contributor.googleauthorDonghee Han-
dc.contributor.googleauthorJi Hyun Lee-
dc.contributor.googleauthorSang-Eun Lee-
dc.contributor.googleauthorJi Min Sung-
dc.contributor.googleauthorSu-Yeon Choi-
dc.contributor.googleauthorEun Ju Chun-
dc.contributor.googleauthorSung Hak Park-
dc.contributor.googleauthorHae-Won Han-
dc.contributor.googleauthorJidong Sung-
dc.contributor.googleauthorHae Ok Jung-
dc.contributor.googleauthorHyuk-Jae Chang-
dc.identifier.doi10.1016/j.ijcard.2018.03.112-
dc.contributor.localIdA01955-
dc.contributor.localIdA03215-
dc.contributor.localIdA03490-
dc.contributor.localIdA04811-
dc.relation.journalcodeJ01093-
dc.identifier.eissn1874-1754-
dc.identifier.pmid29887457-
dc.subject.keywordCoronary artery calcification-
dc.subject.keywordDiabetes mellitus-
dc.subject.keywordOptimal glycemic control-
dc.contributor.alternativeNameSung, Ji Min-
dc.contributor.alternativeNameLee, Jee Hyun-
dc.contributor.alternativeNameChang, Hyuck Jae-
dc.contributor.alternativeNameHan, Donghee-
dc.contributor.affiliatedAuthorSung, Ji Min-
dc.contributor.affiliatedAuthorLee, Jee Hyun-
dc.contributor.affiliatedAuthorChang, Hyuck Jae-
dc.contributor.affiliatedAuthorHan, Donghee-
dc.citation.volume266-
dc.citation.startPage250-
dc.citation.endPage253-
dc.identifier.bibliographicCitationInternational Journal of Cardiology, Vol.266 : 250-253, 2018-
Appears in Collections:
5. Research Institutes (연구소) > Yonsei Cardiovascular Research Institute (심혈관연구소) > 1. Journal Papers
2. College of Dentistry (치과대학) > Others (기타) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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