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급성 심근 경색증환자에서 심근 관류의 평가 : 심근 조영심초음파를 이용한 연구

Other Titles
 Assessment of Myocardial Perfusion in Patients with Acute Myocardial Infarction : Myocardial Contrast Echocardiography Using Intravenous Infusion of Microbubbles 
 임세중  ;  하종원  ;  최동훈  ;  고충원  ;  이동일  ;  편욱범  ;  전국진  ;  안신기  ;  이문형  ;  장양수  ;  이종두  ;  정남식 
 Journal of the Korean Society of Echocardiography (한국심초음파학회지), Vol.9(1) : 10-16, 2001 
Journal Title
 Journal of the Korean Society of Echocardiography (한국심초음파학회지) 
Issue Date
Myocardial contrast echocardiography ; Acute myocardial infarction
Background:Unlike 99mTc-Sestamibi, microbubbles used during myocardial contrast echocardiography (MCE) exist only in the vascular space. Therefore, there may be a difference in the pattern of myocardial perfusion between MCE and 99mTc-Sestamibi Single-Photon Emission Computed Tomography (SPECT) in acute myocardial infarction (AMI). Objectives:The purpose of this study was to assess myocardial perfusion using MCE with intravenous infusion of perfluorocarbon-exposed sonicated dextrose albumin microbubbles (IV MCE), and to compare it with SPECT and MCE with intracoronary injection of sonicated Hexabrix (IC MCE). Methods:Seventeen patients with AMI (male 13, age 59.5±8.8 years, anterior MI 10) underwent IV MCE at 8.1±3.7 days after onset. SPECT and IC MCE were also performed at 1.2±1.0 days and 2.0±1.5 days from IV MCE respectively. Any revascularization procedures were not performed between three studies. Perfusion defect by three methods was scored semiquantitatively as 1:normal perfusion, 0.5:moderate defect, and 0:severe defect at 16 segments of the left ventricle. Results:1) Perfusion defect in infarction territory was detected in 15 patients with SPECT, 12 patients with IV MCE and 11 patients with IC MCE. 2) Concordance of perfusion score at each segment was 93% between IV MCE and IC MCE, 65% between IV MCE and SPECT, and 64% between IC MCE and SPECT. 3) With IV MCE, perfusion defect was observed in all 32 segments which were considered as having defect (score 0 and 0.5) by IC MCE. However, defect by IV MCE was found only in 31 out of 108 segments considered as having defect by SPECT. Conclusion:In the assessment of myocardial perfusion in pts with AMI, IV MCE and IC MCE showed similar results. However, there was some discrepancy in the extent of perfusion defect between MCE studies and SPECT
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Medical Education (의학교육학과)
Yonsei Authors
안신기(Ahn, Shin Ki)
이문형(Lee, Moon Hyoung)
임세중(Rim, Se Joong)
장양수(Jang, Yang Soo)
정남식(Chung, Nam Sik)
최동훈(Choi, Dong Hoon)
하종원(Ha, Jong Won)
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