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3,4 diaminopyridine for the treatment of myasthenia gravis with electrophysiological patterns of Lambert-Eaton myasthenic syndrome

Authors
 Moon Kyu Lee  ;  Il Nam Sunwoo  ;  Seung Min Kim 
Citation
 JOURNAL OF CLINICAL NEUROSCIENCE, Vol.50 : 194-198, 2018 
Journal Title
 JOURNAL OF CLINICAL NEUROSCIENCE 
ISSN
 0967-5868 
Issue Date
2018
MeSH
4-Aminopyridine/analogs & derivatives* ; 4-Aminopyridine/therapeutic use ; Adult ; Aged ; Cholinesterase Inhibitors/therapeutic use ; Female ; Humans ; Lambert-Eaton Myasthenic Syndrome/drug therapy* ; Male ; Middle Aged ; Myasthenia Gravis/drug therapy* ; Potassium Channel Blockers/therapeutic use* ; Pyridostigmine Bromide/therapeutic use
Keywords
3,4-Diaminopyridine ; Anti-acetylcholine receptor antibody ; Lambert-Eaton myasthenic syndrome ; Myasthenia gravis ; Treatment
Abstract
3,4-Diaminopyridine (34DAP) is a presynaptic transmission enhancer. Its efficacy for Lambert-Eaton myasthenic syndrome (LEMS) and myasthenia gravis (MG) was demonstrated. However, there are cases sharing the characteristics of both disease and the effect of 34DAP in "gray zone" patients is sparse. Recently, we prescribed 34DAP to five anti-acetylcholine receptor antibody-positive MG patients with electrophysiological LEMS patterns and three LEMS patients, and carefully monitored the responses. Sero-positive MG patients exhibited more favorable responses than LEMS patients. The combination of 34DAP and pyridostigmine resulted in the best outcomes. No significant side effects were recorded during the follow-up period. In conclusion, this study results provide evidence that 34DAP could be effective in sero-positive MG patients with pre-synaptic dysfunction.
Full Text
https://www.sciencedirect.com/science/article/pii/S0967586817313322
DOI
10.1016/j.jocn.2018.01.024
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Seung Min(김승민) ORCID logo https://orcid.org/0000-0002-4384-9640
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/163317
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