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Moonlighting Activity of Secreted Inflammation- Regulatory Proteins

Authors
 Joo-Heon Yoon  ;  Junsun Ryu  ;  Seung Joon Baek 
Citation
 YONSEI MEDICAL JOURNAL, Vol.59(4) : 463-469, 2018 
Journal Title
 YONSEI MEDICAL JOURNAL 
ISSN
 0513-5796 
Issue Date
2018
MeSH
Cell Biology ; Cytoplasm ; Humans ; Inflammation* ; Protein Binding ; Proteins/chemistry ; Proteins/physiology* ; Transcription Factors
Keywords
Inflammation ; moonlighting protein ; multiple function ; secretion
Abstract
Moonlighting proteins exhibit multiple activities in different cellular compartments, and their abnormal regulation could play an important role in many diseases. To date, many proteins have been identified with moonlighting activity, and more such proteins are being gradually identified. Among the proteins that possess moonlighting activity, several secreted proteins exhibit multiple activities in different cellular locations, such as the extracellular matrix, nucleus, and cytoplasm. While acute inflammation starts rapidly and generally disappears in a few days, chronic inflammation can last for months or years. This is generally because of the failure to eliminate the cause of inflammation, along with repeated exposure to the inflammatory agent. Chronic inflammation is now considered as an overwhelming burden to the general wellbeing of patients and noted as an underlying cause of several diseases. Moonlighting proteins can contribute to the process of chronic inflammation; therefore, it is imperative to overview some proteins that exhibit multiple functions in inflammatory diseases. In this review, we will focus on inflammation, particularly unravelling several well-known secreted proteins with multiple functions in different cellular locations.
Files in This Item:
T201802793.pdf Download
DOI
10.3349/ymj.2018.59.4.463
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Otorhinolaryngology (이비인후과학교실) > 1. Journal Papers
Yonsei Authors
Yoon, Joo Heon(윤주헌)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/163308
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