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Successful Intrathecal Baclofen Therapy for Intractable Paroxysmal Sympathetic Hyperactivity in Patient with Pontine Hemorrhage: A case report

DC FieldValueLanguage
dc.contributor.author김나영-
dc.contributor.author김용욱-
dc.date.accessioned2018-09-28T08:56:43Z-
dc.date.available2018-09-28T08:56:43Z-
dc.date.issued2018-
dc.identifier.issn0362-5664-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/163252-
dc.description.abstractParoxysmal sympathetic hyperactivity (PSH) is characterized by increased activity of the sympathetic nervous system. Although several treatments have been proposed for PSH, their efficacies are uncertain. We report a case of a patient with intractable PSH after pontine hemorrhage who was treated with intrathecal baclofen (ITB). A 61-year-old man was diagnosed with pontine hemorrhage expanding to the bilateral midbrain. Beginning 2 weeks after onset, he developed paroxysmal hyperthermia, tachycardia, tachypnea, hypertension, and generalized dystonic movements. Several medications were administered to the patient, including fentanyl patch, dantrolene, gabapentin, and β blockers. Nevertheless, PSH episodes continued to occur more than twice per day. Seven months after onset, we performed a trial of ITB injection, which led to reduced severity and frequency of PSH. Therefore, the ITB therapy was implanted. Continuous ITB was initiated at a rate of 100 μg/d, which was gradually increased up to 200 μg/d. Oral medications were tapered off. No PSH episode occurred for 4 weeks. Our findings suggest that ITB therapy may be used to manage intractable PSH. Intrathecal baclofen may inhibit postsynaptic activity and suppress sympathetic activity via the stimulation of γ-aminobutyric acid B receptors the brain.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherLippincott Williams & Wilkins-
dc.relation.isPartOfClinical Neuropharmacology-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleSuccessful Intrathecal Baclofen Therapy for Intractable Paroxysmal Sympathetic Hyperactivity in Patient with Pontine Hemorrhage: A case report-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Rehabilitation Medicine-
dc.contributor.googleauthorHyeon Su Kim-
dc.contributor.googleauthorNa Young Kim-
dc.contributor.googleauthorYong Wook Kim-
dc.identifier.doi10.1097/WNF.0000000000000289-
dc.contributor.localIdA00350-
dc.contributor.localIdA00750-
dc.relation.journalcodeJ00591-
dc.identifier.eissn1537-162X-
dc.identifier.pmid30001249-
dc.identifier.urlhttps://insights.ovid.com/pubmed?pmid=30001249-
dc.subject.keywordpontine hemorrhage-
dc.subject.keywordparoxysmal sympathetic hyperactivity-
dc.subject.keywordintrathecal baclofen therapy-
dc.contributor.alternativeNameKim, Na Young-
dc.contributor.alternativeNameKim, Yong Wook-
dc.contributor.affiliatedAuthorKim, Na Young-
dc.contributor.affiliatedAuthorKim, Yong Wook-
dc.citation.volume41-
dc.citation.number4-
dc.citation.startPage138-
dc.citation.endPage141-
dc.identifier.bibliographicCitationClinical Neuropharmacology, Vol.41(4) : 138-141, 2018-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Rehabilitation Medicine (재활의학교실) > 1. Journal Papers

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