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Renoprotective effects of dexmedetomidine against ischemia-reperfusion injury in streptozotocin-induced diabetic rats.

DC FieldValueLanguage
dc.contributor.author김승현-
dc.contributor.author오영준-
dc.contributor.author최용선-
dc.contributor.author전지혜-
dc.date.accessioned2018-09-28T08:56:14Z-
dc.date.available2018-09-28T08:56:14Z-
dc.date.issued2018-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/163240-
dc.description.abstractBACKGROUND: Diabetic patients are susceptible to renal ischemia-reperfusion injury, which leads to perioperative complications. Activation of NOD-like receptor protein 3 (NLRP3) inflammasome participates in the development of diabetes, and contributes to renal ischemia-reperfusion injury. Dexmedetomidine (DEX), a highly selective α2-adrenoreceptor agonist, shows renoprotective effects against ischemia-reperfusion injury. We aimed to elucidate the effects, underlying mechanisms, and optimal timing of DEX treatment in diabetic rats. METHODS: Male Sprague-Dawley rats (n = 12 per group) were randomly divided into normal-sham, diabetes-sham, diabetes-ischemia-reperfusion-control, diabetes-ischemia-reperfusion-DEX-pre-treatment, and diabetes-ischemia-reperfusion-DEX-post-treatment groups. Renal ischemia-reperfusion injury was induced in diabetic rats by occlusion of both renal arteries for 45 min, followed by reperfusion for 24 h. DEX (10 μg/kg) was administered intraperitoneally 1 h before ischemia (pre-treatment) or upon reperfusion (post-treatment). After reperfusion, renal tissue was biochemically and histopathologically evaluated. RESULTS: DEX treatment attenuated ischemia reperfusion-induced increase in NLRP3, caspase-1, IL-1β, phospho-AKT, and phospho-ERK signaling. Moreover, oxidative stress injury, inflammatory reactions, apoptosis, and renal tubular damage were favorably modulated by DEX treatment. Furthermore, post-reperfusion treatment with DEX was significantly more effective than pre-treatment in modulating NLRP3 inflammasome, AKT and ERK signaling, and oxidative stress. CONCLUSIONS: This study shows that the protective effects of DEX in renal ischemia-reperfusion injury are preserved in diabetic conditions and may potentially provide a basis for the use of DEX in clinical treatment of renal ischemia-reperfusion injury.-
dc.description.statementOfResponsibilityopen-
dc.formatapplication/pdf-
dc.languageEnglish-
dc.publisherPublic Library of Science-
dc.relation.isPartOfPLoS One-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleRenoprotective effects of dexmedetomidine against ischemia-reperfusion injury in streptozotocin-induced diabetic rats.-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Anesthesiology and Pain Medicine-
dc.contributor.googleauthorSeung Hyun Kim-
dc.contributor.googleauthorJi Hae Jun-
dc.contributor.googleauthorJu Eun Oh-
dc.contributor.googleauthorEun-Jung Shin-
dc.contributor.googleauthorYoung Jun Oh-
dc.contributor.googleauthorYong Seon Choi-
dc.identifier.doi10.1371/journal.pone.0198307-
dc.contributor.localIdA05098-
dc.contributor.localIdA02389-
dc.contributor.localIdA04119-
dc.relation.journalcodeJ02540-
dc.identifier.eissn1932-6203-
dc.identifier.pmid30114208-
dc.contributor.alternativeNameKim, Seung Hyun-
dc.contributor.alternativeNameOh, Young Jun-
dc.contributor.alternativeNameChoi, Yong Seon-
dc.contributor.affiliatedAuthorKim, Seung Hyun-
dc.contributor.affiliatedAuthorOh, Young Jun-
dc.contributor.affiliatedAuthorChoi, Yong Seon-
dc.citation.volume13-
dc.citation.number8-
dc.citation.startPagee0198307-
dc.identifier.bibliographicCitationPLoS One, Vol.13(8) : e0198307, 2018-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) > 1. Journal Papers

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