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한국인 건선관절염 환자의 임상적 특징과 치료양상에 대한후향적 단일기관 연구

Other Titles
 Clinical Features and Treatment Patterns of Korean Patients with Psoriatic Arthritis: A Retrospective Single-center Study 
Authors
 이민석  ;  이재원  ;  김태균  ;  이민걸 
Citation
 Korean Journal of Dermatology (대한피부과학회지), Vol.56(5) : 308-313, 2018 
Journal Title
 Korean Journal of Dermatology (대한피부과학회지) 
ISSN
 0494-4739 
Issue Date
2018
Keywords
Biologics ; Psoriasis ; Psoriatic arthritis
Abstract
Background: Psoriatic arthritis (PsA) is a seronegative inflammatory arthritis associated with psoriasis. The prevalence of PsA varies across different countries, and a few previous studies have reported that 9∼17% of Korean patients with psoriasis present with PsA. However, limited data are available regarding the clinical features and treatment of Korean patients with PsA. Objective: To evaluate the clinical features of Korean patients with PsA and the treatment modalities used in the real-world setting. Methods: This study was a retrospective single-center study. We analyzed 101 Korean patients who had been diagnosed with PsA based on the Classification Criteria for Psoriatic Arthritis (CASPAR). We reviewed the patients’ medical records, Psoriasis Area and Severity Index (PASI) score, body surface area (BSA), manifestation pattern of PsA, and treatment course. Results: Our study included 101 patients. The mean age was 50.7 years. The mean PASI score was 8.6, and the mean BSA was 11.5%. Spondylitis was the most common manifestation (40.6%). In most patients, psoriatic lesions preceded the onset of PsA (57.4%). Psoriasis and PsA occurred simultaneously in 32.7%, and PsA developed prior to psoriasis in 9.9% of patients. The administration of nonsteroidal anti-inflammatory drugs (NSAIDs) was the most commonly utilized treatment strategy (82.2%), followed by the use of methotrexate and sulfasalazine. Twenty-two patients were treated with biologics with favorable efficacy. Conclusion: Spondylitis was the most common manifestation in patients. NSAIDs, methotrexate and sulfasalazine were the drugs most commonly used to treat Korean patients with PsA. Dermatologists should be mindful of this entity, and during history taking at the patient’s initial visit, those with psoriasis should be asked, “Do you have any pain or swelling of joints?” to ensure early diagnosis of PsA.
Full Text
http://kiss.kstudy.com/thesis/thesis-view.asp?key=3611789
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Dermatology (피부과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Tae-Gyun(김태균) ORCID logo https://orcid.org/0000-0002-2116-4579
Lee, Min Geol(이민걸) ORCID logo https://orcid.org/0000-0001-7040-5335
Lee, Jae Won(이재원)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/163162
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