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Serum persistent organic pollutants levels and stroke risk

 Jung-eun Lim  ;  Sunju Lee  ;  Sunmi Lee  ;  Sun Ha Jee 
 ENVIRONMENTAL POLLUTION, Vol.233 : 855-861, 2018 
Journal Title
Issue Date
Adult ; Brain Ischemia ; Cohort Studies ; Dichlorodiphenyl Dichloroethylene/blood ; Environmental Exposure/statistics & numerical data* ; Environmental Pollutants/blood* ; Female ; Gas Chromatography-Mass Spectrometry ; Humans ; Hypertension ; Male ; Middle Aged ; Polychlorinated Biphenyls/blood ; Proportional Hazards Models ; Republic of Korea/epidemiology ; Risk ; Smoking/epidemiology ; Stroke/epidemiology*
Endocrine disruptors ; Polychlorinated biphenyls ; Prospective studies ; Stroke
Knowledge of environmental risk factors for stroke and their role are limited. We performed a case-cohort study to evaluate the association between serum persistent organic pollutants (POPs) level and stroke risk. 526 subcohort members and 111 stroke incidence cases were identified from the Korean Cancer Prevention Study-II. Serum levels of POPs were measured using gas chromatography/high-resolution mass spectrometry. The hazard ratios (HRs) for stroke (ischemic, hemorrhagic, and all stroke types) were estimated using the weighted Cox regression model. Age, sex, body mass index, smoking status, physical activity, family history of cardiovascular disease, and hypertension were adjusted in the weighted Cox regression model. After adjusting for potential confounding factors, increased risk for stroke was observed among participants with serum concentration of p,p'-DDE in the highest tertile compared to those in the lowest tertile (HR = 4.10, 95% CI: 1.58, 10.59). A similar association was estimated for PCB118 (HR = 2.33, 95% CI: 1.04, 5.22), PCB156 (HR = 3.42, 95% CI: 1.42, 8.23), and PCB138 (HR = 3.80, 95% CI: 1.48, 9.76). For TEQ, stroke was three times as likely to occur among subjects with TEQ in the highest tertile compared to those in the lowest tertile (HR = 3.12, 95% CI: 1.27, 7.65). PCBs were positively associated with ischemic stroke, but not with hemorrhagic stroke. Elevated serum POPs levels were associated with an increased risk of stroke, especially ischemic stroke.
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4. Graduate School of Public Health (보건대학원) > Graduate School of Public Health (보건대학원) > 1. Journal Papers
Yonsei Authors
Jee, Sun Ha(지선하) ORCID logo https://orcid.org/0000-0001-9519-3068
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