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Increased Thrombogenicity in Chronic Renal Failure in a Rat Model Induced by 5/6 Ablation/Infarction.

 Tae-Jin Song  ;  Il Kwon  ;  Honglim Piao  ;  Jee-Eun Lee  ;  Kyeo-Rye Han  ;  Yoonkyung Chang  ;  Hyung Jung Oh  ;  Hyun-Jung Choi  ;  Kyung-Yul Lee  ;  Yong-Jae Kim  ;  Ki-Hwan Han  ;  Ji Hoe Heo 
 Yonsei Medical Journal, Vol.59(6) : 754-759, 2018 
Journal Title
 Yonsei Medical Journal 
Issue Date
Animals ; Blood Coagulation* ; Blood Coagulation Tests ; Blood Platelets/metabolism* ; Hemostasis* ; Infarction ; Kidney ; Kidney Failure, Chronic/blood* ; Kidney Failure, Chronic/therapy ; Male ; Rats ; Rats, Sprague-Dawley ; Thrombelastography/methods* ; Thrombosis
Chronic renal failure ; ferric chloride ; thromboelastometry ; thrombosis
PURPOSE: Abnormalities in hemostasis and coagulation have been suggested in chronic renal failure (CRF). In this study, we compared processes of thrombus formation between rats with CRF and those with normal kidney function. MATERIALS AND METHODS: CRF was induced by 5/6 ablation/infarction of the kidneys in Sprague-Dawley rats, and surviving rats after 4 weeks were used. Ferric chloride (FeCl₃)-induced thrombosis in the carotid artery was induced to assess thrombus formation. Whole blood clot formation was evaluated using rotational thromboelastometry (ROTEM). Platelet aggregation was assessed with impedance platelet aggregometry. RESULTS: FeCl₃-induced thrombus formation was initiated faster in the CRF group than in the control group (13.2±1.1 sec vs. 17.8±1.0 sec, p=0.027). On histological examination, the maximal diameters of thrombi were larger in the CRF group than in the control group (394.2±201.1 μm vs. 114.0±145.1 μm, p=0.039). In extrinsic pathway ROTEM, the CRF group showed faster clot initiation (clotting time, 59.0±7.3 sec vs. 72.8±5.0 sec, p=0.032) and increased clot growth kinetics (α angle, 84.8±0.2° vs. 82.0±0.6°, p=0.008), compared to the control group. Maximal platelet aggregation rate was higher in the CRF group than in the control group (58.2±0.2% vs. 44.6±1.2%, p=0.006). CONCLUSION: Our study demonstrated that thrombogenicity is increased in rats with CRF. An activated extrinsic coagulation pathway may play an important role in increasing thrombogenicity in CRF.
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1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
Yonsei Authors
이경열(Lee, Kyung Yul) ORCID logo https://orcid.org/0000-0001-5585-7739
최현정(Choi, Hyun-Jung) ORCID logo https://orcid.org/0000-0003-3695-3420
허지회(Heo, Ji Hoe) ORCID logo https://orcid.org/0000-0001-9898-3321
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