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Comparison of Clinical Characteristics and Surgical Outcomes of Cystic and Solid Vestibular Schwannomas

 Ji Hyuk Han  ;  Kwang Ha Baek  ;  Young Woo Lee  ;  Young Kyun Hur  ;  Hyun Ji Kim  ;  In Seok Moon 
 OTOLOGY & NEUROTOLOGY, Vol.39(5) : e381-e386, 2018 
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OBJECTIVE: The aim of this study was to compare the clinical characteristics of cystic vestibular schwannomas (CVSs) and solid vestibular schwannomas (SVSs). STUDY DESIGN: Retrospective review. SETTING: Tertiary care center. PATIENTS: A total of 220 patients who underwent microsurgery for vestibular schwannomas between 2007 and 2016. INTERVENTION: CVSs were defined as cystic components >/=1/3 of total tumor volume based on automated volume measurement. Tumors larger than 5 cm were defined as large tumors. MAIN OUTCOME MEASURES: Clinical characteristics and surgical outcomes, including preoperative symptoms, hearing threshold, vestibular function, tumor volume, extent of resection, facial nerve outcomes, and nonfacial complications were evaluated. RESULTS: Tumor volume was significantly larger in CVSs (20.44 +/- 13.85 cm in CVSs; 4.75 +/- 6.48 cm in SVSs, p < 0.001) and the proportion of larger tumors was also greater in CVSs (66.0% in CVSs; 11.4% in SVSs, p < 0.001). Preoperative dizziness was highly prevalent in CVSs (32.1% in CVSs; 18.6% in SVSs, p = 0.038) and postoperative facial nerve outcomes were significantly worse in CVSs (67.9% favorable rate in CVSs; 87.4% favorable rate in SVSs, p = 0.001). When the comparison was limited to large tumors, no clinical characteristics or surgical outcomes were significantly different. Tumor volume had a greater effect than tumor type on the surgical outcomes. The odds ratios for subtotal resection and unfavorable facial nerve function with a large tumor were 5.77 (confidence interval [CI]: 1.52-21.95, p = 0.010) and 5.34 (CI: 1.41-20.22, p = 0.014), respectively. CONCLUSION: CVSs tend to be larger than SVSs. Tumor volume, not cystic component, is thought to be a major determinant of surgical outcomes.
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1. College of Medicine (의과대학) > Dept. of Otorhinolaryngology (이비인후과학교실) > 1. Journal Papers
Yonsei Authors
Moon, In Seok(문인석) ORCID logo https://orcid.org/0000-0002-3951-5074
Baek, Kwangha(백광하)
Lee, Young Woo(이영우)
Han, Ji Hyuk(한지혁)
Hur, Young Kyun(허영균) ORCID logo https://orcid.org/0000-0001-7057-4294
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