50 56

Cited 3 times in

Impact of Non-obstructive left main disease on the progression of coronary artery disease: A PARADIGM substudy

 Jonathan R Weir-McCall  ;  Philipp Blanke  ;  Stephanie L Sellers  ;  Amir A Ahmadi  ;  Daniele Andreini  ;  Matthew J Budoff  ;  Filippo Cademartiri  ;  Kavitha Chinnaiyan  ;  Jung Hyun Choi  ;  Eun Ju Chun  ;  Edoardo Conte  ;  Ilan Gottlieb  ;  Martin Hadamitzky  ;  Yong Jin Kim  ;  Byoung Kwon Lee  ;  Sang-Eun Lee  ;  Erica Maffei  ;  Hugo Marques  ;  Gianluca Pontone  ;  Gilbert L Raff  ;  Sanghoon Shin  ;  Ji Min Sung  ;  Peter Stone  ;  Habib Samady  ;  Renu Virmani  ;  Jagat Narula  ;  Daniel S Berman  ;  Leslee J Shaw  ;  Jeroen J Bax  ;  Fay Y Lin  ;  James K Min  ;  Hyuk-Jae Chang  ;  Jonathon A Leipsic 
 Journal of Cardiovascular Computed Tomography, Vol.12(3) : 231-237, 2018 
Journal Title
 Journal of Cardiovascular Computed Tomography 
Issue Date
Coronary computed tomography angiography ; Left main coronary artery disease ; Natural history
BACKGROUND: The aim of the study is examine the impact of non-obstructive (<50%stenosis) left main (LM) disease on the natural history of coronary artery disease using serial coronary computed tomography angiography (CTA). METHODS: CTAs from the PARADIGM (Progression of atherosclerotic plaque determined by computed tomographic angiography imaging) study, a prospective multinational registry of patients who underwent serial CTA at a >/=2 year interval were analyzed. Those without evidence of CAD on their baseline scan were excluded, as were those with obstructive left main disease. Coronary artery vessels and their branches underwent quantification of: plaque volume and composition; diameter stenosis; presence of high-risk plaque. RESULTS: Of 944 (62+/-9 years, 60% male) who had evidence of CAD at baseline, 444 (47%) had LM disease. Those with LM disease had a higher baseline plaque volume (194.8+/-221mm3 versus 72.9+/-84.3mm3, p<0.001) and a higher prevalence of high-risk plaque (17.5% versus 13%, p<0.001) than those without LM disease. On multivariable general linear model, patients with LM disease had greater annual rates of progression of total (26.5+/-31.4mm3/yr versus 14.9+/-20.1mm3/yr, p<0.001) and calcified plaque volume (17+/-24mm3/yr versus 7+/-11mm3/yr, p<0.001), with no difference in fibrous, fibrofatty or necrotic core plaque components. CONCLUSION: The presence of non-obstructive LM disease is associated with greater rates of plaque progression and a higher prevalence of high-risk plaque throughout the entire coronary artery tree compared to CAD without LM involvement. Our data suggests that non-obstructive LM disease may be a marker for an aggressive phenotype of CAD that may benefit from more intensive treatment strategies.
Files in This Item:
T201801965.pdf Download
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실)
Yonsei Authors
장혁재(Chang, Hyuck Jae) ORCID logo https://orcid.org/0000-0002-6139-7545
RIS (EndNote)
XLS (Excel)
사서에게 알리기


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.