Cited 69 times in
A Multi-layered Quantitative In Vivo Expression Atlas of the Podocyte Unravels Kidney Disease Candidate Genes
DC Field | Value | Language |
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dc.contributor.author | 지헌영 | - |
dc.date.accessioned | 2018-08-28T17:25:43Z | - |
dc.date.available | 2018-08-28T17:25:43Z | - |
dc.date.issued | 2018 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/162592 | - |
dc.description.abstract | Damage to and loss of glomerular podocytes has been identified as the culprit lesion in progressive kidney diseases. Here, we combine mass spectrometry-based proteomics with mRNA sequencing, bioinformatics, and hypothesis-driven studies to provide a comprehensive and quantitative map of mammalian podocytes that identifies unanticipated signaling pathways. Comparison of the in vivo datasets with proteomics data from podocyte cell cultures showed a limited value of available cell culture models. Moreover, in vivo stable isotope labeling by amino acids uncovered surprisingly rapid synthesis of mitochondrial proteins under steady-state conditions that was perturbed under autophagy-deficient, disease-susceptible conditions. Integration of acquired omics dimensions suggested FARP1 as a candidate essential for podocyte function, which could be substantiated by genetic analysis in humans and knockdown experiments in zebrafish. This work exemplifies how the integration of multi-omics datasets can identify a framework of cell-type-specific features relevant for organ health and disease. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Cell Press | - |
dc.relation.isPartOf | CELL REPORTS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | A Multi-layered Quantitative In Vivo Expression Atlas of the Podocyte Unravels Kidney Disease Candidate Genes | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Pharmacology | - |
dc.contributor.googleauthor | Markus M Rinschen | - |
dc.contributor.googleauthor | Markus Godel | - |
dc.contributor.googleauthor | Florian Grahammer | - |
dc.contributor.googleauthor | Stefan Zschiedrich | - |
dc.contributor.googleauthor | Martin Helmstadter | - |
dc.contributor.googleauthor | Oliver Kretz | - |
dc.contributor.googleauthor | Mostafa Zarei | - |
dc.contributor.googleauthor | Daniela A Braun | - |
dc.contributor.googleauthor | Sebastian Dittrich | - |
dc.contributor.googleauthor | Caroline Pahmeyer | - |
dc.contributor.googleauthor | Patricia Schroder | - |
dc.contributor.googleauthor | Carolin Teetzen | - |
dc.contributor.googleauthor | HeonYung Gee | - |
dc.contributor.googleauthor | Ghaleb Daouk | - |
dc.contributor.googleauthor | Martin Pohl | - |
dc.contributor.googleauthor | Elisa Kuhn | - |
dc.contributor.googleauthor | Bernhard Schermer | - |
dc.contributor.googleauthor | Victoria Kuttner | - |
dc.contributor.googleauthor | Melanie Boerries | - |
dc.contributor.googleauthor | Hauke Busch | - |
dc.contributor.googleauthor | Mario Schiffer | - |
dc.contributor.googleauthor | Carsten Bergmann | - |
dc.contributor.googleauthor | Marcus Kruger | - |
dc.contributor.googleauthor | Friedhelm Hildebrandt | - |
dc.contributor.googleauthor | Joern Dengjel | - |
dc.contributor.googleauthor | Thomas Benzing | - |
dc.contributor.googleauthor | Tobias B Huber | - |
dc.identifier.doi | 10.1016/j.celrep.2018.04.059 | - |
dc.contributor.localId | A03971 | - |
dc.relation.journalcode | J00488 | - |
dc.identifier.eissn | 2211-1247 | - |
dc.identifier.pmid | 29791858 | - |
dc.subject.keyword | end-stage renal disease | - |
dc.subject.keyword | focal segmental glomerulosclerosis | - |
dc.subject.keyword | hereditary nephrotic syndrome | - |
dc.subject.keyword | kinase | - |
dc.subject.keyword | metabolism | - |
dc.subject.keyword | proteinuria | - |
dc.subject.keyword | proteostasis | - |
dc.subject.keyword | pulse SILAC | - |
dc.subject.keyword | slit diaphragm | - |
dc.subject.keyword | systems biology | - |
dc.contributor.alternativeName | Gee, Heon Yung | - |
dc.contributor.affiliatedAuthor | Gee, Heon Yung | - |
dc.citation.volume | 23 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | 2495 | - |
dc.citation.endPage | 2508 | - |
dc.identifier.bibliographicCitation | CELL REPORTS, Vol.23(8) : 2495-2508, 2018 | - |
dc.identifier.rimsid | 60172 | - |
dc.type.rims | ART | - |
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