Cited 15 times in

Effects of Post Ischemia-Reperfusion Treatment with Trimetazidine on Renal Injury in Rats: Insights on Delayed Renal Fibrosis Progression

DC Field Value Language
dc.contributor.author곽영란-
dc.contributor.author박진하-
dc.contributor.author심재광-
dc.contributor.author전지혜-
dc.date.accessioned2018-08-28T17:25:00Z-
dc.date.available2018-08-28T17:25:00Z-
dc.date.issued2018-
dc.identifier.issn1942-0900-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/162577-
dc.description.abstractEven after recovery from acute kidney injury, glomeruli remain vulnerable to further injury by way of interstitial fibrosis. This study is aimed at elucidating the effects of post ischemia-reperfusion (I/R) treatment with trimetazidine on the progression to renal fibrosis as well as short- and intermediate-term aspects. Trimetazidine 3 mg/kg or 0.9% saline was given intraperitoneally once upon reperfusion or daily thereafter for 5 d or 8 w. Renal histologic changes and related signaling proteins were assessed. After 24 h, post I/R treatment with trimetazidine significantly reduced serum blood urea nitrogen and creatinine levels and tubular injury accompanied with upregulation of hypoxia-inducible factor- (HIF-) 1α, vascular endothelial growth factor (VEGF), and Bcl-2 expression. After 5 d, post I/R treatment with trimetazidine reduced renal tubular cell necrosis and apoptosis with upregulation of HIF-1α-VEGF and tissue inhibitors of metalloproteinase activities, attenuation of matrix metalloproteinase activities, and alteration of the ratio of Bax to Bcl-2 levels. After 8 w, however, post I/R treatment with trimetazidine did not modify the progression of renal fibrosis. In conclusion, post I/R treatment with trimetazidine allows ischemic kidneys to regain renal function and structure more rapidly compared to nontreated kidneys, but not enough to resolute renal fibrosis in long-term aspect.-
dc.description.statementOfResponsibilityopen-
dc.formatapplication/pdf-
dc.languageEnglish-
dc.publisherHindawi Pub. Corp.-
dc.relation.isPartOfOXIDATIVE MEDICINE AND CELLULAR LONGEVITY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleEffects of Post Ischemia-Reperfusion Treatment with Trimetazidine on Renal Injury in Rats: Insights on Delayed Renal Fibrosis Progression-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Anesthesiology and Pain Medicine-
dc.contributor.googleauthorJin Ha Park-
dc.contributor.googleauthorJi Hae Jun-
dc.contributor.googleauthorJae-Kwang Shim-
dc.contributor.googleauthorEun Jung Shin-
dc.contributor.googleauthorEunah Shin-
dc.contributor.googleauthorYoung-Lan Kwak-
dc.identifier.doi10.1155/2018/1072805-
dc.contributor.localIdA00172-
dc.contributor.localIdA01704-
dc.contributor.localIdA02205-
dc.relation.journalcodeJ02455-
dc.identifier.eissn1942-0994-
dc.contributor.alternativeNameKwak, Young Lan-
dc.contributor.alternativeNamePark, Jin Ha-
dc.contributor.alternativeNameShim, Jae Kwang-
dc.contributor.affiliatedAuthorKwak, Young Lan-
dc.contributor.affiliatedAuthorPark, Jin Ha-
dc.contributor.affiliatedAuthorShim, Jae Kwang-
dc.citation.volume2018-
dc.citation.startPage1072805-
dc.identifier.bibliographicCitationOXIDATIVE MEDICINE AND CELLULAR LONGEVITY, Vol.2018 : 1072805, 2018-
dc.identifier.rimsid60157-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Research Institute (부설연구소) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.