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Reference values of neutrophil-lymphocyte ratio, lymphocyte-monocyte ratio, platelet-lymphocyte ratio, and mean platelet volume in healthy adults in South Korea

 Jeong Soo Lee  ;  Na Young Kim  ;  Se Hee Na  ;  Young Hoon Youn  ;  Cheung Soo Shin 
 MEDICINE, Vol.97(26) : e11138, 2018 
Journal Title
Issue Date
Adult ; Blood Platelets/cytology ; Female ; Humans ; Leukocyte Count/*methods ; Lymphocytes/cytology ; Male ; Mean Platelet Volume/*methods ; Middle Aged ; Neutrophils/cytology ; Platelet Count/*methods ; Prognosis ; Reference Values ; Republic of Korea ; Retrospective Studies
There is a growing interest in research aimed at better understanding the disease status or predicting the prognosis of patients with simple blood tests associated with systemic inflammation. The neutrophil-lymphocyte ratio (NLR), lymphocyte-monocyte ratio (LMR), platelet-lymphocyte ratio (PLR), and mean platelet volume (MPV) can be used as factors to determine the prognosis of patients in various clinical situations. However, reference values for these attributes based on large, healthy populations have yet to be determined.From January 2014 to December 2016, data from routine blood analyses were collected from healthy patients in the checkup center of a tertiary hospital in Seoul, South Korea. Retrospective data review was then performed on an electronic medical record system. Data were treated anonymously as only age, sex, body mass index, medical history including cancer diagnosis, medications, and smoking status were considered. After the initial screen, we had a collection of 12,160 samples from patients without any medical history, including cancer treatment. This patient pool consisted of 6268 (51.5%, median age 47 years) and 5892 (48.5%, median age 46 years) male and female patients, respectively. The mean NLR across all ages was 1.65 (0.79), and the values for men and women were 1.63 (0.76) and 1.66 (0.82), respectively. The mean LMR, PLR, and MPV were 5.31 (1.68), 132.40 (43.68), and 10.02 (0.79), respectively. This study provides preliminary reference data on LMR, PLR, and MPV from different age and sex groups in South Korea. The results suggest that different cutoff values should be applied to the various patient populations.
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1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Na Young(김나영) ORCID logo https://orcid.org/0000-0003-3685-2005
Na, Se Hee(라세희) ORCID logo https://orcid.org/0000-0003-4208-0769
Shin, Cheung Soo(신증수) ORCID logo https://orcid.org/0000-0001-7829-8458
Youn, Young Hoon(윤영훈) ORCID logo https://orcid.org/0000-0002-0071-229X
Lee, Jeong Soo(이정수) ORCID logo https://orcid.org/0000-0002-8947-3706
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