132 152

Cited 3 times in

Genetic structures of invasive Streptococcus pneumoniae isolates from Korean children obtained between 1995 and 2013

 Ki Wook Yun  ;  Eun Hwa Choi  ;  Hoan Jong Lee  ;  Jin Han Kang  ;  Kyung-Hyo Kim  ;  Dong Soo Kim  ;  Yae-Jean Kim  ;  Byung Wook Eun  ;  Sung Hee Oh  ;  Hye-Kyung Cho  ;  Young Jin Hong  ;  Kwang Nam Kim  ;  Nam Hee Kim  ;  Yun-Kyung Kim  ;  Hyunju Lee  ;  Taekjin Lee  ;  Hwang Min Kim  ;  Eun Young Cho  ;  Chun Soo Kim  ;  Su Eun Park  ;  Chi Eun Oh  ;  Dae Sun Jo  ;  Young Youn Choi  ;  Jina Lee 
 BMC INFECTIOUS DISEASES, Vol.18(1) : 268, 2018 
Journal Title
Issue Date
Children ; Invasive pneumococcal diseases ; Multilocus sequence typing ; Pneumococcal conjugate vaccine
BACKGROUND: Understanding the population genetics of pneumococci will allow detection of changes in the prevalence of circulating genotypes and evidence for capsular switching. We aimed to analyze the genetic structure of invasive pneumococcal isolates obtained from children before and after the use of pneumococcal conjugate vaccines (PCVs) in Korea. METHODS: A total of 285 invasive pneumococcal isolates were analyzed using serotyping, multilocus sequence typing, and antimicrobial susceptibility testing. We classified the isolation year to pre-PCV7 (1995-2003; n = 70), post-PCV7 (2004-2010; n = 142), and post-PCV13 (2011-2013; n = 73) periods. RESULTS: Of the 10 clonal complexes (CCs), antibiotic-resistant international clones, CC320 (31.6%), CC81 (14.7%), and CC166 (6.7%) were the main complexes. Serotype 19A was the main serotype of CC320 throughout the periods. Serotypes of CC81 mainly comprised of 23F (53.3%) in pre-PCV7 period and replaced by non-vaccine types (NVTs; 6C [10%], 13 [30%], 15A [40%], and 15B/C [20%]) in post-PCV13 period. The main serotype responsible for CC166 also changed from 9 V (80%) in pre-PCV7 to NVT 11A (50%) in post-PCV13 periods. Non-susceptibility to penicillin (42.3%) was the highest in CC320, increasing from 0 to 76%. CONCLUSION: The genetic structures of invasive pneumococcal isolates in Korean children have changed concomitantly with serotype after the implementation of PCVs.
Files in This Item:
T201801924.pdf Download
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Dong Soo(김동수)
사서에게 알리기


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.