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Regional differences in the incidence of tuberculosis among patients with newly diagnosed diabetes mellitus

Authors
 Bo Ram Yang  ;  Young Ae Kang  ;  Eun Young Heo  ;  Bo Kyung Koo  ;  Nam-Kyong Choi  ;  Seung-Sik Hwang  ;  Chang-Hoon Lee 
Citation
 Clinical Respiratory Journal, Vol.12(4) : 1732-1738, 2018 
Journal Title
 Clinical Respiratory Journal 
ISSN
 1752-6981 
Issue Date
2018
Keywords
diabetes ; epidemiology ; pulmonary infection ; tuberculosis
Abstract
OBJECTIVE: There are regional differences in the burden of tuberculosis (TB). Although these differences might be explained by regional differences in the risk factors of TB, whether such risk factors are actually associated with the regional differences in the TB burden remains unclear. This study aimed to investigate the relationship between the risk factors of and regional differences in TB incidence. METHODS: A cohort study applying nationwide claims database in Republic of Korea included patients newly diagnosed with type 2 diabetes mellitus (DM) in 2009. The main outcome was the incidence of TB defined based on the diagnostic codes combined with anti-tuberculosis treatment repeated within 90 days. Sixteen regions were categorized into 3 groups according to the age- and sex-standardized TB incidence rates. Multivariate logistic regression analysis adjusted for risk factors was performed to identify the determinants of the regional differences in TB incidence. RESULTS: Among 331 601 participants newly diagnosed with type 2 DM and with no history of previous TB, 1216 TB cases were observed. The regional TB incidence rates ranged between 2.3 and 5.9/1000 patients. Multivariate analyses did not identify any determinants of regional differences in the TB incidence among the various risk factors, including age, sex, health care utilization, co-morbidities, medication and treatment and complications of DM. Similarly, temperature, humidity and latent TB infection rate also did not affect the results. CONCLUSIONS: Although substantial regional differences in the TB incidence rate were observed among patients with newly diagnosed DM, no determinants of regional difference were identified among the risk factors.
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/162543
Full Text
https://onlinelibrary.wiley.com/doi/abs/10.1111/crj.12737
DOI
10.1111/crj.12737
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실)
Yonsei Authors
강영애(Kang, Young Ae) ORCID logo https://orcid.org/0000-0002-7783-5271
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