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Association between Changes in Serum 25-Hydroxyvitamin D Levels and Survival in Patients with Breast Cancer Receiving Neoadjuvant Chemotherapy

 Ji Su Kim  ;  Caspar Christian Haule  ;  Joo Heung Kim  ;  Sung Mook Lim  ;  Kwang Hyun Yoon  ;  Jee Ye Kim  ;  Hyung Seok Park  ;  Seho Park  ;  Seung Il Kim  ;  Young Up Cho  ;  Byeong-Woo Park 
 Journal of Breast Cancer, Vol.21(2) : 134-141, 2018 
Journal Title
 Journal of Breast Cancer 
Issue Date
Breast neoplasms ; Neoadjuvant therapy ; Survival ; Treatment outcome ; Vitamin D
Purpose: We investigated the changes in serum 25-hydroxyvitamin D (25[OH]D) levels before and after neoadjuvant chemotherapy (NCT) and the associations with pathologic complete response (pCR) and survival in patients with breast cancer. Methods: Serum 25(OH)D concentrations were measured pre- and post-NCT in 374 patients between 2010 and 2013. Based on a cutoff of 20 ng/mL, patients were categorized into "either sufficient" or "both deficient" groups. The associations with clinicopathological data, including pCR and survival, were analyzed using multivariable analyses. Results: Patients with either pre- or post-NCT sufficient 25(OH)D levels accounted for 23.8%, and the overall pCR rate was 25.9%. Most patients showed 25(OH)D deficiency at diagnosis and 65.8% showed decreased serum levels after NCT. Changes in 25(OH)D status were associated with postmenopause status, rural residence, baseline summer examination, and molecular phenotype, but not pCR. No association between survival and 25(OH)D status was found, including in the subgroup analyses based on molecular phenotypes. Conclusion: Most Korean patients with breast cancer showed vitamin D deficiency at diagnosis and a significant decrease in the serum concentration after NCT. No association with oncologic outcomes was found. Therefore, although optimal management for vitamin D deficiency is urgent for skeletal health, further research is warranted to clearly determine the prognostic role of vitamin D in patients with breast cancer who are candidates for NCT.
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1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실)
Yonsei Authors
김승일(Kim, Seung Il)
김지수(Kim, Ji Su)
김지예(Kim, Jee Ye) ORCID logo https://orcid.org/0000-0003-3936-4410
박병우(Park, Byeong Woo) ORCID logo https://orcid.org/0000-0003-1353-2607
박세호(Park, Se Ho) ORCID logo https://orcid.org/0000-0001-8089-2755
박형석(Park, Hyung Seok) ORCID logo https://orcid.org/0000-0001-5322-6036
윤광현(Yoon, Kwang Hyun)
조영업(Cho, Young Up) ORCID logo https://orcid.org/0000-0003-2936-410X
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