Cited 58 times in
Successful transdermal allergen delivery and allergen-specific immunotherapy using biodegradable microneedle patches
DC Field | Value | Language |
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dc.contributor.author | 곡원호 | - |
dc.contributor.author | 노지연 | - |
dc.contributor.author | 박경희 | - |
dc.contributor.author | 신정우 | - |
dc.contributor.author | 용태순 | - |
dc.contributor.author | 이광훈 | - |
dc.contributor.author | 이정수 | - |
dc.contributor.author | 정경용 | - |
dc.date.accessioned | 2018-08-28T17:20:46Z | - |
dc.date.available | 2018-08-28T17:20:46Z | - |
dc.date.issued | 2018 | - |
dc.identifier.issn | 0142-9612 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/162499 | - |
dc.description.abstract | Allergen-specific immunotherapy (SIT) is an effective treatment modality for allergic diseases such as atopic dermatitis (AD). However, frequent visits over a 3-year period as well as looming adverse events tend to discourage patient compliance. Therefore, a more convenient, effective, and safe method of SIT is needed. For several decades, use of microneedles has been promoted as an efficient and precise transdermal drug delivery method. In this study, we developed Dermatophagoides farinae (D. farinae) extract (DfE)-loaded microneedle patches, and evaluated their safety and efficacy as a novel SIT method. After 4 weeks of patch application, efficient allergen delivery and successful induction of immune response to DfE were demonstrated in mice, with no apparent adverse events. AD-induced NC/Nga mice received microneedle immunotherapy (MNIT) (10 mug), subcutaneous immunotherapy (SCIT) (10 mug), SCIT (100 mug), or placebo. Both MNIT (10 mug) and SCIT (100 mug) treatments improved clinical and histologic manifestations of AD skin lesions, altered immunoglobulin production, dampened Th2 cellular response, and boosted Treg infiltrates, without significant side effects; whereas SCIT (10 mug) or placebo subsets failed to show any effects. Based on the favorable safety and efficacy profiles demonstrated in mice by MNIT in the current study, we believe that MNIT may serve as a new SIT modality. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Elsevier Science | - |
dc.relation.isPartOf | BIOMATERIALS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Allergens/*administration & dosage | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Atopic/pathology/*therapy Dermatitis | - |
dc.subject.MESH | Dermatophagoides farinae/*immunology | - |
dc.subject.MESH | Immunologic/*instrumentation Desensitization | - |
dc.subject.MESH | Animal Disease Models | - |
dc.subject.MESH | Drug Delivery Systems/*instrumentation | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Hyaluronic Acid/chemistry | - |
dc.subject.MESH | Subcutaneous Injections | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Inbred Strains Mice | - |
dc.subject.MESH | Needles | - |
dc.subject.MESH | *Transdermal Patch | - |
dc.subject.MESH | Treatment Outcome | - |
dc.title | Successful transdermal allergen delivery and allergen-specific immunotherapy using biodegradable microneedle patches | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Dermatology | - |
dc.contributor.googleauthor | Ji Hye Kim | - |
dc.contributor.googleauthor | Jung U Shin | - |
dc.contributor.googleauthor | Seo Hyeong Kim | - |
dc.contributor.googleauthor | Ji Yeon Noh | - |
dc.contributor.googleauthor | Hye Ran Kim | - |
dc.contributor.googleauthor | Jungsoo Lee | - |
dc.contributor.googleauthor | Howard Chu | - |
dc.contributor.googleauthor | Kyoung Yong Jeong | - |
dc.contributor.googleauthor | Kyung Hee Park | - |
dc.contributor.googleauthor | Jung Dong Kim | - |
dc.contributor.googleauthor | Hong Kee Kim | - |
dc.contributor.googleauthor | Do Hyeon Jeong | - |
dc.contributor.googleauthor | Tai-Soon Yong | - |
dc.contributor.googleauthor | Jung-Won Park | - |
dc.contributor.googleauthor | Kwang Hoon Lee | - |
dc.identifier.doi | 10.1016/j.biomaterials.2017.10.013 | - |
dc.contributor.localId | A04510 | - |
dc.contributor.localId | A01296 | - |
dc.contributor.localId | A01427 | - |
dc.contributor.localId | A02149 | - |
dc.contributor.localId | A02424 | - |
dc.contributor.localId | A02674 | - |
dc.contributor.localId | A04637 | - |
dc.contributor.localId | A03572 | - |
dc.relation.journalcode | J00312 | - |
dc.identifier.eissn | 1878-5905 | - |
dc.identifier.pmid | 29032329 | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0142961217306415 | - |
dc.subject.keyword | Allergen-specific immunotherapy | - |
dc.subject.keyword | Atopic dermatitis | - |
dc.subject.keyword | Dermatophagoides farinae | - |
dc.subject.keyword | Microneedle | - |
dc.subject.keyword | NC/Nga mouse | - |
dc.contributor.alternativeName | Chu, Howard | - |
dc.contributor.alternativeName | Noh, Ji Yeon | - |
dc.contributor.alternativeName | Park, Kyung Hee | - |
dc.contributor.alternativeName | Shin, Jung U | - |
dc.contributor.alternativeName | Yong, Tai Soon | - |
dc.contributor.alternativeName | Lee, Kwang Hoon | - |
dc.contributor.alternativeName | Lee, Jungsoo | - |
dc.contributor.alternativeName | Jeong, Kyoung Yong | - |
dc.contributor.affiliatedAuthor | Chu, Howard | - |
dc.contributor.affiliatedAuthor | Noh, Ji Yeon | - |
dc.contributor.affiliatedAuthor | Park, Kyung Hee | - |
dc.contributor.affiliatedAuthor | Shin, Jung U | - |
dc.contributor.affiliatedAuthor | Yong, Tai Soon | - |
dc.contributor.affiliatedAuthor | Lee, Kwang Hoon | - |
dc.contributor.affiliatedAuthor | Lee, Jungsoo | - |
dc.contributor.affiliatedAuthor | Jeong, Kyoung Yong | - |
dc.citation.volume | 150 | - |
dc.citation.startPage | 38 | - |
dc.citation.endPage | 48 | - |
dc.identifier.bibliographicCitation | BIOMATERIALS, Vol.150 : 38-48, 2018 | - |
dc.identifier.rimsid | 60080 | - |
dc.type.rims | ART | - |
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