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Site-specific expression of amine oxidases in breast cancer metastases

Authors
 Yoon Jin Cha  ;  Woo Hee Jung  ;  Ja Seung Koo 
Citation
 Tumor Biology, Vol.40(5) : 1010428318776822, 2018 
Journal Title
 Tumor Biology 
ISSN
 1010-4283 
Issue Date
2018
MeSH
Amine Oxidase (Copper-Containing)/*biosynthesis ; Breast Neoplasms/*enzymology/pathology ; Female ; Humans ; Middle Aged ; Monoamine Oxidase/*biosynthesis ; Neoplasm Metastasis ; Proportional Hazards Models ; Protein-Lysine 6-Oxidase/*biosynthesis
Keywords
Breast cancer ; amine oxidase ; immunohistochemistry ; metastasis
Abstract
We aimed to evaluate the expression of amine oxidase-related proteins in metastatic breast cancer tissue and determine its clinical implication. A tissue microarray was constructed from a total of 126 metastatic breast tumors (31 bone metastases (24.6%), 36 brain metastases (28.6%), 11 liver metastases (8.7%), and 48 lung metastases (38.1%)). Immunohistochemical staining for amine oxidase-related proteins (lysyl oxidase, diamine oxidase, and monoamine oxidase A and B) was performed. In metastatic breast cancer tissue, lysyl oxidase ( p = 0.001), tumoral diamine oxidase ( p = 0.003), stromal diamine oxidase ( p = 0.047), and stromal monoamine oxidase B ( p = 0.002) were differentially expressed in different metastatic sites. Bone metastases showed low expression of lysyl oxidase, tumoral diamine oxidase, and stromal diamine oxidase. We observed high expression of lysyl oxidase in brain metastases, tumoral diamine oxidase in liver metastases, stromal diamine oxidase in lung metastases, and stromal monoamine oxidase B in bone metastases. Lysyl oxidase positivity was associated with progesterone receptor negativity ( p = 0.001), and monoamine oxidase A positivity was associated with human epidermal growth factor receptor-2 negativity ( p = 0.003) and the luminal A subtype ( p = 0.003). On univariate analysis shorter overall survival was associated with stromal diamine oxidase negativity ( p = 0.008), especially in lung metastases ( p = 0.025), and stromal monoamine oxidase B positivity ( p < 0.001). Stromal monoamine oxidase B positivity was an independent prognostic factor for shorter overall survival in multivariate Cox analysis (hazard ratio, 4.069; 95% confidence interval, 1.649-10.04; p = 0.002). Finally, in metastatic breast cancer, amine oxidase-related proteins were differentially expressed in a manner specific to metastatic site, and stromal monoamine oxidase B expression was correlated with prognosis.
Full Text
http://journals.sagepub.com/doi/10.1177/1010428318776822
DOI
10.1177/1010428318776822
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실)
Yonsei Authors
구자승(Koo, Ja Seung) ORCID logo https://orcid.org/0000-0003-4546-4709
정우희(Jung, Woo Hee)
차윤진(Cha, Yoon Jin) ORCID logo https://orcid.org/0000-0002-5967-4064
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/162483
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