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Feasibility of Left Atrial Appendage Occlusion for Left Atrial Appendage Thrombus in Patients With Persistent Atrial Fibrillation

 Oh-Hyun Lee  ;  Jung-Sun Kim  ;  Hui-Nam Pak  ;  Geu-Ru Hong  ;  Chi Young Shim  ;  Jae-Sun Uhm  ;  In-Jeong Cho  ;  Boyoung Joung  ;  Cheol-Woong Yu  ;  Hyun-Jong Lee  ;  Woong-Chol Kang  ;  Eun-Seok Shin  ;  Rak-Kyeong Choi  ;  Do-Sun Lim  ;  Yangsoo Jang 
 American Journal of Cardiology, Vol.121(12) : 1534-1539, 2018 
Journal Title
 American Journal of Cardiology 
Issue Date
This study sought to investigate the safety of percutaneous left atrial appendage (LAA) occlusion for stroke prevention in patients with nonvalvular atrial fibrillation who have LAA thrombus. From October 2010 to October 2016, LAA occlusions were performed in facilities within a Korean multicenter registry in patients without (n = 132) or with (n = 10) LAA thrombus (detected during preprocedural assessments). The incidences of periprocedural complications, including stroke, pericardial tamponade, major bleeding, and device embolization, were assessed and compared between the groups. The incidence of periprocedural complications was not significantly different between patients with and without LAA thrombus (0% vs 5% [6 of 132]; p = 0.49). During the mean 23.2 +/- 17.5-month follow-up duration, 7 major adverse cardiac events occurred (1 cardiovascular death, 6 ischemic strokes), but overall event rates were not significantly different between the groups (14% vs 9%; p = 0.47). In conclusion, percutaneous LAA occlusion in nonvalvular atrial fibrillation patients with LAA thrombus may be a safe and feasible alternative to anticoagulation in select patients at a high risk of bleeding or contraindication to anticoagulation, or in whom anticoagulation failed to prevent stroke.
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1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실)
Yonsei Authors
김중선(Kim, Jung Sun) ORCID logo https://orcid.org/0000-0003-2263-3274
박희남(Pak, Hui Nam) ORCID logo https://orcid.org/0000-0002-3256-3620
심지영(Shim, Chi Young)
엄재선(Uhm, Jae Sun) ORCID logo https://orcid.org/0000-0002-1611-8172
이오현(Lee, Oh Hyun) ORCID logo https://orcid.org/0000-0001-7070-7720
장양수(Jang, Yang Soo) ORCID logo https://orcid.org/0000-0002-2169-3112
정보영(Joung, Bo Young) ORCID logo https://orcid.org/0000-0001-9036-7225
조인정(Cho, In Jeong)
홍그루(Hong, Geu Ru)
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