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Combination of clinical and laboratory characteristics may serve as a potential diagnostic marker for torsion on mature cystic teratomas

Authors
 Ji Yun Lee  ;  Whan Shin  ;  Jeong Sook Kim  ;  Joo Hyun Park  ;  SiHyun Cho 
Citation
 Obstetrics & Gynecology Science, Vol.61(3) : 386-394, 2018 
Journal Title
 Obstetrics & Gynecology Science 
ISSN
 2287-8572 
Issue Date
2018
Keywords
Leukocyte ; Neoplasms ; Teratoma
Abstract
Objective: The objective of this study was to evaluate clinical and laboratory characteristics of torsion on mature cystic teratomas (MCTs). In addition, we examined whether these factors could be helpful in diagnosing MCT torsion. Methods: A retrospective medical record review was conducted for 384 patients who had undergone surgery and histologically verified ovarian MCTs at single university hospital between July 2006 and May 2017. Patients with or without torsion groups were compared with respect to clinical presentation, laboratory findings and surgical course. In addition, statistically significant indicators of the factors were additionally evaluated for diagnostic value. Results: White blood cell (WBC) count, neutrophil count, neutrophil to lymphocyte (N/L) ratio, and tumor size were higher in the torsion group (n=24) than in the control group (n=360; P</=0.005 for all). The age was younger in the torsion group than in the control (P=0.009). In the area under the curve (AUC) of the 5 factors obtained by univariate and multivariate logistic regression, the age was 0.657, the WBC count was 0.838, the neutrophil count was 0.806, the N/L ratio was 0.725, and the cyst size was 0.705. Receiver operating characteristic analysis indicated that the AUC for the combined use of age, WBC count, neutrophil count, N/L ratio, and tumor size was 0.898 (95% confidence interval, 0.833-0.962; P<0.001). Conclusion: The combined measurement of age, WBC count, neutrophil count, N/L ratio, and tumor size may be used as a potential diagnostic marker for the torsion on MCTs.
Files in This Item:
T201801514.pdf Download
DOI
10.5468/ogs.2018.61.3.386
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Obstetrics and Gynecology (산부인과학교실)
Yonsei Authors
김정숙(Kim, Jeong Sook)
박주현(Park, Joo Hyun)
이지윤(Lee, Ji Yun)
조시현(Cho, Si Hyun) ORCID logo https://orcid.org/0000-0003-2718-6645
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/162399
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