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Effects of 5-alpha reductase inhibitors: new insights on benefits and harms

Authors
 Joo Yong Lee  ;  Kang Su Cho 
Citation
 Current Opinion in Urology, Vol.28(3) : 288-293, 2018 
Journal Title
 Current Opinion in Urology 
ISSN
 0963-0643 
Issue Date
2018
Abstract
PURPOSE OF REVIEW: The use of 5-alpha reductase inhibitors (5ARIs) for the treatment of benign prostatic hyperplasia (BPH) and other diseases has been proposed and studied. However, the controversy about its benefits and harms for other diseases has persisted. In this review, we will discuss the newly identified effects of 5ARIs based on recently published studies. RECENT FINDINGS: These drugs are currently recommended in clinical guidelines for BPH. However, the reporting of adverse effects, including sexual dysfunction as well as neurologic, endocrine, and cardiovascular effects, have been controversial. There are reports of additional effects of 5ARI in prostate cancer and bladder cancer. Although 5ARIs have been prescribed for the treatment of androgenic alopecia (AGA), postfinasteride syndrome can result, with symptoms that range from sexual dysfunction to muscle atrophy. SUMMARY: Clinical applications of 5ARIs have been established for the treatment of BPH and AGA from a series of randomized controlled trials. The adverse effects of 5ARIs affect only a small proportion of treated patients and can be resolved with discontinued treatment. It will be necessary to establish the mechanism by which 5ARIs elicit these effects through better designed studies.
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/162388
Full Text
http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=00042307-201805000-00012&D=ovft&PDF=y
DOI
10.1097/mou.0000000000000497
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Urology (비뇨의학교실)
Yonsei Authors
이주용(Lee, Joo Yong) ORCID logo https://orcid.org/0000-0002-3470-1767
조강수(Cho, Kang Su)
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