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OASL1 Traps Viral RNAs in Stress Granules to Promote Antiviral Responses

Authors
 Ji-Seon Kang  ;  Yune-Sahng Hwang  ;  Lark Kyun Kim  ;  Sujung Lee  ;  Wook-Bin Lee  ;  Jeongsil Kim-Ha  ;  Young-Joon Kim 
Citation
 Molecules and Cells, Vol.41(3) : 214-223, 2018 
Journal Title
 Molecules and Cells 
ISSN
 1016-8478 
Issue Date
2018
Keywords
OASL1 ; anti-viral response ; stress granule ; type I interferon
Abstract
Oligoadenylate synthetase (OAS) protein family is the major interferon (IFN)-stimulated genes responsible for the activation of RNase L pathway upon viral infection. OAS-like (OASL) is also required for inhibition of viral growth in human cells, but the loss of one of its mouse homolog, OASL1, causes a severe defect in termination of type I interferon production. To further investigate the antiviral activity of OASL1, we examined its subcellular localization and regulatory roles in IFN production in the early and late stages of viral infection. We found OASL1, but not OASL2, formed stress granules trapping viral RNAs and promoted efficient RLR signaling in early stages of infection. Stress granule formation was dependent on RNA binding activity of OASL1. But in the late stages of infection, OASL1 interacted with IRF7 transcripts to inhibit translation resulting in down regulation of IFN production. These results implicate that OASL1 plays context dependent functions in the antiviral response for the clearance and resolution of viral infections.
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/162363
Files in This Item:
T201801445.pdf Download
DOI
10.14348/molcells.2018.2293
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부)
Yonsei Authors
김락균(Kim, Lark Kyun) ORCID logo https://orcid.org/0000-0001-5983-4470
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