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Development of a Screening Tool to Predict Chronic Kidney Disease Risk in Post-nephrectomy Living Kidney Donors

Authors
 J S Park  ;  H K Ahn  ;  J Na  ;  H H Lee  ;  Y E Yoon  ;  M G Yoon  ;  W K Han 
Citation
 Transplantation Proceedings, Vol.50(4) : 993-997, 2018 
Journal Title
 Transplantation Proceedings 
ISSN
 0041-1345 
Issue Date
2018
Abstract
Few studies have examined the long-term risks of kidney removal to donors despite the increase of frequency in kidney transplantation. This is the 1st study to develop prediction models of chronic kidney disease (CKD) for the 1-year period after donor nephrectomy in living donors. A prospective cohort of patients who underwent donor nephrectomy from March 1, 2006, to December 31, 2016, at the Severance Hospital, Seoul, South Korea, was used. CKD was defined as a glomerular filtration rate (GFR) <60 mL/min/1.73 m(2). GFR was estimated with the use of the abbreviated Modification in Diet and Renal Disease Study equation. Patients with a previous CKD history or estimated GFR <60 mL/min/1.73 m(2) were excluded, and those with 1-year post-nephrectomy follow-up were included. Among 440 patients who underwent donor nephrectomy, 144 (32.7%) developed a first-time onset of a GFR <60 mL/min/1.73 m(2) by 1 year after surgery. Our logistic regression models derived from these 3 variables predicted CKD with an area under the receiver operating characteristic curve of 0.796, an accuracy of 70.9%, and a sensitivity of 66.2% and specificity of 80.6%. This model could assist with decision making about potential donors and for surveillance of those at risk of post-nephrectomy CKD.
Full Text
https://www.sciencedirect.com/science/article/pii/S0041134518301039
DOI
10.1016/j.transproceed.2018.01.034
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Urology (비뇨의학교실) > 1. Journal Papers
Yonsei Authors
Na, Joon Chae(나준채) ORCID logo https://orcid.org/0000-0003-4449-8472
Park, Jee Soo(박지수) ORCID logo https://orcid.org/0000-0001-9976-6599
Yoon, Young Eun(윤영은)
Lee, Hyung Ho(이형호)
Han, Woong Kyu(한웅규) ORCID logo https://orcid.org/0000-0002-2527-4046
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/162359
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