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The Neutrophil-Lymphocyte Ratio and Platelet-Lymphocyte Ratio Are Prognostic Factors in Patients with Locally Advanced Pancreatic Cancer Treated with Chemoradiotherapy

 Byung Min Lee  ;  Seung Yeun Chung  ;  Jee Suk Chang  ;  Kyong Joo Lee  ;  Jinsil Seong 
 Gut and Liver, Vol.12(3) : 342-352, 2018 
Journal Title
 Gut and Liver 
Issue Date
Lymphocyte count ; Neutrophils ; Pancreatic neoplasms ; Platelet count ; Prognosis
Background/Aims: We investigated whether inflammatory markers such as neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) independently and in combination would be significant prognostic factors for survival in patients with locally advanced pancreatic cancer. Methods: A total of 497 patients with locally advanced pancreatic cancer who received neoadjuvant or definitive chemoradiotherapy from 2005 to 2015 were evaluated. We divided the patients into groups according to the median values of NLR and PLR: NLR1.89 (n=156), NLR>/=1.89 (n=341), PLR 149 (n=248) and PLR >/=149 (n=249). Results: For NLR 1.89 and >/=1.89 groups, respectively, the 1-year overall survival (OS) rates were 73.2% and 60.8% (p0.001) and 1-year progression-free survival (PFS) rates were 43.9% and 31.3% (p0.001). For PLR 149 and >/=149 groups, respectively, the 1-year OS rates were 68.1% and 61.3% (p=0.029) and 1-year PFS rates were 37.9% and 32.5% (p=0.027). Patients with both high NLR and high PLR showed the worst OS and PFS rates compared with those with both lower NLR and lower PLR. Conclusions: Elevated pretreatment NLR and PLR independently and in combination significantly predicted poor OS and PFS.
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1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실)
Yonsei Authors
성진실(Seong, Jin Sil) ORCID logo https://orcid.org/0000-0003-1794-5951
장지석(Chang, Jee Suk Paul) ORCID logo https://orcid.org/0000-0001-7685-3382
정승연(Chung, Seung Yeun) ORCID logo https://orcid.org/0000-0002-3877-6950
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