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The Neutrophil-Lymphocyte Ratio and Platelet-Lymphocyte Ratio Are Prognostic Factors in Patients with Locally Advanced Pancreatic Cancer Treated with Chemoradiotherapy

Authors
 Byung Min Lee  ;  Seung Yeun Chung  ;  Jee Suk Chang  ;  Kyong Joo Lee  ;  Jinsil Seong 
Citation
 GUT AND LIVER, Vol.12(3) : 342-352, 2018 
Journal Title
 GUT AND LIVER 
ISSN
 1976-2283 
Issue Date
2018
Keywords
Lymphocyte count ; Neutrophils ; Pancreatic neoplasms ; Platelet count ; Prognosis
Abstract
Background/Aims: We investigated whether inflammatory markers such as neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) independently and in combination would be significant prognostic factors for survival in patients with locally advanced pancreatic cancer. Methods: A total of 497 patients with locally advanced pancreatic cancer who received neoadjuvant or definitive chemoradiotherapy from 2005 to 2015 were evaluated. We divided the patients into groups according to the median values of NLR and PLR: NLR1.89 (n=156), NLR>/=1.89 (n=341), PLR 149 (n=248) and PLR >/=149 (n=249). Results: For NLR 1.89 and >/=1.89 groups, respectively, the 1-year overall survival (OS) rates were 73.2% and 60.8% (p0.001) and 1-year progression-free survival (PFS) rates were 43.9% and 31.3% (p0.001). For PLR 149 and >/=149 groups, respectively, the 1-year OS rates were 68.1% and 61.3% (p=0.029) and 1-year PFS rates were 37.9% and 32.5% (p=0.027). Patients with both high NLR and high PLR showed the worst OS and PFS rates compared with those with both lower NLR and lower PLR. Conclusions: Elevated pretreatment NLR and PLR independently and in combination significantly predicted poor OS and PFS.
Files in This Item:
T201801405.pdf Download
DOI
10.5009/gnl17216
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실) > 1. Journal Papers
Yonsei Authors
Seong, Jin Sil(성진실) ORCID logo https://orcid.org/0000-0003-1794-5951
Chang, Jee Suk Paul(장지석) ORCID logo https://orcid.org/0000-0001-7685-3382
Chung, Seung Yeun(정승연) ORCID logo https://orcid.org/0000-0002-3877-6950
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/162340
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