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Increased store-operated Ca(2+) entry mediated by GNB5 and STIM1

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dc.contributor.author박순홍-
dc.contributor.author신동민-
dc.date.accessioned2018-08-28T17:09:57Z-
dc.date.available2018-08-28T17:09:57Z-
dc.date.issued2018-
dc.identifier.issn1226-4512-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/162326-
dc.description.abstractRecent human genetic studies have shown that Gbeta5 is related to various clinical symptoms, such as sinus bradycardia, cognitive disability, and attention deficit hyperactivity disorder. Although the calcium signaling cascade is closely associated with a heterotrimeric G-protein, the function of Gbeta5 in calcium signaling and its relevance to clinical symptoms remain unknown. In this study, we investigated the in vitro changes of store-operated calcium entry (SOCE) with exogenous expression of Gbeta5. The cells expressing Gbeta5 had enhanced SOCE after depletion of calcium ion inside the endoplasmic reticulum. Gbeta5 also augmented Stim1- and Orai1-dependent SOCE. An ORAI1 loss-of-function mutant did not show inhibition of Gbeta5-induced SOCE, and a STIM1-ERM truncation mutant showed no enhancement of SOCE. These results suggested a novel role of GNB5 and Stim1, and provided insight into the regulatory mechanism of SOCE.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisher대한약리학회-
dc.relation.isPartOfKOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleIncreased store-operated Ca(2+) entry mediated by GNB5 and STIM1-
dc.typeArticle-
dc.contributor.collegeCollege of Dentistry-
dc.contributor.departmentDept. of Oral Biology-
dc.contributor.googleauthorNamju Kang-
dc.contributor.googleauthorJung Yun Kang-
dc.contributor.googleauthorSoonhong Park-
dc.contributor.googleauthorDong Min Shin-
dc.identifier.doi10.4196/kjpp.2018.22.3.343-
dc.contributor.localIdA01547-
dc.contributor.localIdA02091-
dc.relation.journalcodeJ02104-
dc.identifier.eissn2093-3827-
dc.identifier.pmid29719456-
dc.subject.keywordCa2+ signaling-
dc.subject.keywordGNB5-
dc.subject.keywordOrai1-
dc.subject.keywordSTIM1-
dc.subject.keywordStore-operated Ca2+ entry-
dc.contributor.alternativeNamePark, Soon Hong-
dc.contributor.alternativeNameShin, Dong Min-
dc.contributor.affiliatedAuthorPark, Soon Hong-
dc.contributor.affiliatedAuthorShin, Dong Min-
dc.citation.volume22-
dc.citation.number3-
dc.citation.startPage343-
dc.citation.endPage348-
dc.identifier.bibliographicCitationKOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY, Vol.22(3) : 343-348, 2018-
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실) > 1. Journal Papers

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