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Leptin in the nucleus accumbens blocks the increase of GluA1 phosphorylation induced by acute cocaine administration

Authors
 Jung Won Lee  ;  Wha Young Kim  ;  Jeong-Hoon Kim 
Citation
 Neuroreport, Vol.29(6) : 483-487, 2018 
Journal Title
 Neuroreport 
ISSN
 0959-4965 
Issue Date
2018
Abstract
Leptin in the rat's nucleus accumbens (NAcc) core has previously shown to disrupt the effects of acute administration of cocaine on both locomotor activity and the phosphorylation levels of glycogen synthase kinase 3beta. In the present study, we further measured the phosphorylation levels of GluA1 after bilateral microinjections of leptin in this site followed by acute administration of cocaine. Interestingly, leptin in the NAcc core significantly blocks the increase of GluA1 phosphorylation levels at serine 845 induced by acute administration of cocaine. These effects were not observed for GluA1 phosphorylation levels at serine 831. We have also found additional evidence that glycogen synthase kinase 3beta may play a major role in mediating these processes.
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/162325
Full Text
https://insights.ovid.com/crossref?an=00001756-201804010-00008
DOI
10.1097/wnr.0000000000001001
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Physiology (생리학교실)
Yonsei Authors
김정훈(Kim, Jeong Hoon) ORCID logo https://orcid.org/0000-0001-7095-3729
김화영(Kim, Wha Young)
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