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High resolution metabolomics to determines the risk associated with bisphenol A exposure in humans

Authors
 Seongha Cho  ;  Adnan Khan  ;  Sun Ha Jee  ;  Hee-Seok Lee  ;  Myung-Sil Hwang  ;  Yong Eui Koo  ;  Youngja H Park 
Citation
 Environmental Toxicology and Pharmacology, Vol.58 : 1-10, 2018 
Journal Title
 Environmental Toxicology and Pharmacology 
ISSN
 1382-6689 
Issue Date
2018
Keywords
Bisphenol A ; Fatty acid ; LC-MS ; Metabolomics ; Sphingolipid
Abstract
Although high BPA exposure has been correlated with several metabolic diseases, the underlying mechanisms are unclear. In the present study, a metabolomics approach was used to explore the metabolic variations caused by low or high BPA exposure in female (n=96) and male (n=98) urine. Fatty acid elongation and sphingolipid metabolism were affected by high BPA exposure in males and females. Fatty acid elongation and sphingolipid metabolism were further investigated among age groups consisted of 30-39yrs old, 40-49yrs old, and 50-59yrs old males and females with high or low urinary BPA. High BPA-exposed males in 30s and females in 40s were found with significant disturbance in fatty acid elongation and sphingolipid metabolism, respectively. Additionally, females in 40s showed elevated inflammatory metabolites: 6-ketoprostaglandin E1 and thromboxane. In the present study, we have demonstrated that environmental metabolomics is useful to elucidate the health effects of BPA exposure.
Full Text
https://www.sciencedirect.com/science/article/pii/S1382668917303290
DOI
10.1016/j.etap.2017.12.008
Appears in Collections:
4. Graduate School of Public Health (보건대학원) > Graduate School of Public Health (보건대학원) > 1. Journal Papers
Yonsei Authors
Jee, Sun Ha(지선하) ORCID logo https://orcid.org/0000-0001-9519-3068
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/162322
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