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A Clinical Trial of Combination Neoadjuvant Chemotherapy and Transoral Robotic Surgery in Patients with T3 and T4 Laryngo-Hypopharyngeal Cancer

Authors
 Young Min Park  ;  Ki Chang Keum  ;  Hye Ryun Kim  ;  Byoung Chul Cho  ;  Da Hee Kim  ;  Nam Hoon Cho  ;  Se-Heon Kim 
Citation
 Annals of Surgical Oncology, Vol.25(4) : 864-871, 2018 
Journal Title
 Annals of Surgical Oncology 
ISSN
 1068-9265 
Issue Date
2018
Abstract
BACKGROUND: We conducted a prospective clinical trial of combination neoadjuvant chemotherapy, transoral robotic surgery (TORS), and customized adjuvant therapy in patients with locally advanced laryngo-hypopharyngeal cancer. METHODS: Between September 2008 and August 2016, 35 patients were enrolled in this clinical trial. RESULTS: Twenty patients had hypopharyngeal cancer and 15 had laryngeal cancer. Twenty-nine patients (82.9%) had T3 disease and six patients (17.1%) had T4 disease, while 12 patients (34.3%) had stage III disease and 23 patients (65.7%) had stage IV disease. The 3-year disease-specific survival rate was 82.4% and the 3-year disease-free survival rate was 69.48%. Decannulation was successful in 31 of 34 patients at an average of 18 days postoperatively. Among all patients, 83% exhibited a favorable subjective swallowing status, while five patients (14.4%) became dependent on feeding tubes. CONCLUSIONS: Neoadjuvant chemotherapy combined with TORS and customized adjuvant therapy, based on detailed pathological information, afforded favorable oncological outcomes and preserved organ functionalities in T3-T4 laryngo-hypopharyngeal cancer.
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/162268
Full Text
https://link.springer.com/article/10.1245%2Fs10434-017-6208-5
DOI
10.1245/s10434-017-6208-5
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Otorhinolaryngology (이비인후과학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실)
Yonsei Authors
금기창(Keum, Ki Chang)
김다희(Kim, Da Hee) ORCID logo https://orcid.org/0000-0001-7286-1334
김세헌(Kim, Se Heon)
김혜련(Kim, Hye Ryun) ORCID logo https://orcid.org/0000-0002-1842-9070
조남훈(Cho, Nam Hoon) ORCID logo https://orcid.org/0000-0002-0045-6441
조병철(Cho, Byoung Chul)
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