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Liquid chromatography/mass spectrometry-based plasma metabolic profiling study of escitalopram in subjects with major depressive disorder

Authors
 Raju Bandu  ;  Hyun Jeong Lee  ;  Hyeong Min Lee  ;  Tae Hyon Ha  ;  Heon-Jeong Lee  ;  Se Joo Kim  ;  Kyooseob Ha  ;  Kwang Pyo Kim 
Citation
 Journal of Mass Spectrometry, Vol.53(5) : 385-399, 2018 
Journal Title
 Journal of Mass Spectrometry 
ISSN
 1076-5174 
Issue Date
2018
MeSH
Adult ; Aged ; High Pressure Liquid Chromatography ; Citalopram/blood/*metabolism ; Major/*drug therapy/metabolism Depressive Disorder ; Female ; Humans ; Male ; *Metabolome ; Metabolomics ; Middle Aged ; Tandem Mass Spectrometry ; Young Adult
Keywords
LC/ESI-MS/MS ; escitalopram ; major depressive disorder subjects ; metabolites ; plasma
Abstract
Liquid chromatography-mass spectrometry (LC-MS) method revealed the plasma metabolite profiles in major depressive disorder patients treated with escitalopram (ECTP) (n = 7). Depression severity was assessed according to the 17-item Hamilton Depression Rating Scale. Metabolic profiles were derived from major depressive disorder subject blood samples collected after ECTP treatment. Blood plasma was separated and processed in order to effectively extract metabolites, which were then analyzed using LC-MS. We identified 19 metabolites and elucidated their structures using LC-tandem MS (LC-MS/MS) combined with elemental compositions derived from accurate mass measurements. We further used online H/D exchange experiments to verify the structural elucidations of each metabolite. Identifying molecular metabolites may provide critical insights into the pharmacological and clinical effects of ECTP treatment and may also provide useful information informing the development of new antidepressant treatments. These detailed plasma metabolite analyses may also be used to identify optimal dose concentrations in psychopharmacotherapeutic treatment through drug monitoring, as well as forming the basis for response predictions in depressed subjects.
Full Text
https://onlinelibrary.wiley.com/doi/abs/10.1002/jms.4070
DOI
10.1002/jms.4070
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Se Joo(김세주) ORCID logo https://orcid.org/0000-0002-5438-8210
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/162266
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