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The role of rhFGF-2 soaked polymer membrane for enhancement of guided bone regeneration

DC FieldValueLanguage
dc.contributor.author김형준-
dc.contributor.author문홍석-
dc.contributor.author박영범-
dc.contributor.author심준성-
dc.contributor.author정문규-
dc.contributor.author정한성-
dc.date.accessioned2018-08-28T17:06:25Z-
dc.date.available2018-08-28T17:06:25Z-
dc.date.issued2018-
dc.identifier.issn0920-5063-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/162261-
dc.description.abstractThe purposes of this study are to confirm the role of Fibroblast Growth Factor-2 (FGF-2) in bone regeneration by adding various concentrations of FGF-2 to the collagen membrane and applying it to the Biphasic Calcium Phosphate (BCP) bone graft site for guided bone regeneration, to explore the potential of collagen membrane as FGF-2 carrier, and to determine the optimum FGF concentration for enhancement of bone regeneration. Four bone defects of 8 mm in diameter were created in 18 New Zealand rabbit calvaria. After BCP bone graft, graft material was covered with collagen membranes adding various concentration of FGF-2. The concentration of FGF-2 was set at 1.0, 0.5, 0.1 mg/ml, and same amount of saline was used in the control group. To confirm the bone regeneration over time, six New Zealand rabbits were sacrificed each at 2, 4, and 12 weeks, and the amounts of new bone and residual bone graft material were analyzed by histologic and histomorphometric analysis. Qualitative analyses are also conducted through immunohistochemistry, Tetrate-resistant acid phosphatase (TRAP) stain and Russell-Movat pentachrome stain. As the healing period increased, the formation of new bone increased and the amount of residual graft material decreased in all experimental groups. Immunohistochemistry, TRAP staining and pentachrome staining further showed that the addition of FGF-2 promoted bone regeneration in all experimental groups. It was also confirmed that polymer collagen membrane can be used as a useful carrier of FGF-2 when enhanced early stage of new bone formation is required.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherTaylor and Francis-
dc.relation.isPartOfJournal of Biomaterials Science. Polymer edition-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleThe role of rhFGF-2 soaked polymer membrane for enhancement of guided bone regeneration-
dc.typeArticle-
dc.contributor.collegeCollege of Dentistry-
dc.contributor.departmentDept. of Oral and Maxillofacial Surgery-
dc.contributor.googleauthorSang-Hoon Lee-
dc.contributor.googleauthorYoung-Bum Park-
dc.contributor.googleauthorHong-Seok Moon-
dc.contributor.googleauthorJune-Sung Shim-
dc.contributor.googleauthorHan-Sung Jung-
dc.contributor.googleauthorHyung Jun Kim-
dc.contributor.googleauthorMoon-Kyu Chung-
dc.identifier.doi10.1080/09205063.2017.1354676-
dc.contributor.localIdA01156-
dc.contributor.localIdA01395-
dc.contributor.localIdA01567-
dc.contributor.localIdA02211-
dc.contributor.localIdA03600-
dc.contributor.localIdA03758-
dc.relation.journalcodeJ01261-
dc.identifier.eissn1568-5624-
dc.identifier.pmid28701073-
dc.identifier.urlhttps://www.tandfonline.com/doi/full/10.1080/09205063.2017.1354676-
dc.subject.keywordFGF-2-
dc.subject.keywordPolymer-
dc.subject.keywordcollagen membrane-
dc.subject.keywordguided bone regeneration-
dc.subject.keywordimmunohistochemistry-
dc.subject.keywordpentachrome stain-
dc.contributor.alternativeNameKim, Hyung Jun-
dc.contributor.alternativeNameMoon, Hong Seok-
dc.contributor.alternativeNamePark, Young Bum-
dc.contributor.alternativeNameShim, June Sung-
dc.contributor.alternativeNameChung, Moon Kyu-
dc.contributor.alternativeNameJung, Han Sung-
dc.contributor.affiliatedAuthorKim, Hyung Jun-
dc.contributor.affiliatedAuthorMoon, Hong Seok-
dc.contributor.affiliatedAuthorPark, Young Bum-
dc.contributor.affiliatedAuthorShim, June Sung-
dc.contributor.affiliatedAuthorChung, Moon Kyu-
dc.contributor.affiliatedAuthorJung, Han Sung-
dc.citation.volume29-
dc.citation.number7-9-
dc.citation.startPage825-
dc.citation.endPage843-
dc.identifier.bibliographicCitationJournal of Biomaterials Science. Polymer edition, Vol.29(7-9) : 825-843, 2018-
Appears in Collections:
1. Journal Papers (연구논문) > 2. College of Dentistry (치과대학) > Dept. of Oral and Maxillofacial Surgery (구강악안면외과학교실)
1. Journal Papers (연구논문) > 2. College of Dentistry (치과대학) > Dept. of Prosthodontics (보철과학교실)
1. Journal Papers (연구논문) > 2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실)

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