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Filaria specific antibody response profiling in plasma from anti-retroviral naive Loa loa microfilaraemic HIV-1 infected people

Authors
 Ghislain Donald Njambe Priso  ;  Abel Lissom  ;  Loveline N Ngu  ;  Nadesh N Nji  ;  Jules Colince Tchadji  ;  Thibau Flaurant Tchouangueu  ;  Georgia E Ambada  ;  Carole Stephanie Sake Ngane  ;  Brigitte Laure Dafeu  ;  Larissa Djukouo  ;  Ines Nyebe  ;  Suzanne Magagoum  ;  Apeh Alfred Ngoh  ;  Ouambo Fotso Herve  ;  Rosario Garcia  ;  Anna Gutierrez  ;  Arinze S Okoli  ;  Charles O Esimone  ;  Flobert Njiokou  ;  Chae Gyu Park  ;  Alain Bopda Waffo  ;  Godwin W Nchinda 
Citation
 BMC Infectious Diseases, Vol.18(1) : 160, 2018 
Journal Title
 BMC Infectious Diseases 
Issue Date
2018
Keywords
African eye worm ; HIV-1 ; Loa loa ; Loaisis ; Microfilaraemia
Abstract
BACKGROUND: In West and Central Africa areas of endemic Loa loa infections overlap with regions of high prevalence of human immunodeficiency virus type 1 (HIV-1) infections. Because individuals in this region are exposed to filarial parasites from birth, most HIV-1 infected individuals invariably also have a history of filarial parasite infection. Since HIV-1 infection both depletes immune system and maintains it in perpetual inflammation, this can hamper Loa loa filarial parasite mediated immune modulation, leading to enhanced loaisis. METHODS: In this study we have assessed in plasma from asymptomatic anti-retroviral (ARV) naive Loa loa microfilaraemic HIV-1 infected people the filarial antibody responses specific to a filariasis composite antigen consisting of Wbgp29-BmR1-BmM14-WbSXP. The antibody responses specific to the filariasis composite antigen was determined by enzyme linked immunosorbent assay (ELISA) in plasma from ARV naive Loa loa microfilaraemic HIV-1 infected participants. In addition the filarial antigen specific IgG antibody subclass profiles were also determined for both HIV-1 positive and negative people. RESULTS: Both Loa loa microfilaraemic HIV-1 positive and negative individuals showed significantly higher plasma levels of IgG1 (P < 0.0001), IgG2 (P < 0.0001) and IgM (P < 0.0001) relative to amicrofilaraemic participants. A significant increase in IgE (P < 0.0001) was observed exclusively in Loa loa microfilaraemic HIV-1 infected people. In contrast there was a significant reduction in the level of IgG4 (p < 0.0001) and IgG3 (P < 0.0001) in Loa loa microfilaraemic HIV-1 infected individuals. CONCLUSIONS: Loa loa microfilaraemia in ARV naive HIV-1 infected people through differential reduction of plasma levels of filarial antigen specific IgG3, IgG4 and a significant increase in plasma levels of filarial antigen specific IgE could diminish Loa loa mediated immune-regulation. This in effect can result to increase loaisis mediated immunopathology in antiretroviral naive HIV-1 infected people.
Files in This Item:
T201801166.pdf Download
DOI
10.1186/s12879-018-3072-2
Appears in Collections:
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers
Yonsei Authors
Park, Chae Gyu(박채규) ORCID logo https://orcid.org/0000-0003-1906-1308
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/162227
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