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Association between triglyceride glucose index and arterial stiffness in Korean adults

 Sang Bae Lee  ;  Chul Woo Ahn  ;  Byoung Kwon Lee  ;  Shinae Kang  ;  Ji Sun Nam  ;  Ji Hong You  ;  Min Jin Kim  ;  Min Kyung Kim  ;  Jong Suk Park 
 Cardiovascular Diabetology, Vol.17(1) : 41, 2018 
Journal Title
 Cardiovascular Diabetology 
Issue Date
Arterial stiffness ; Insulin resistance ; Pulse wave velocity ; Triglyceride glucose index
BACKGROUND: The triglyceride glucose (TyG) index has been suggested as a simple surrogate marker of insulin resistance. However, there are limited data regarding the association between the TyG index and arterial stiffness in adults. Therefore, we evaluated the relationship between the TyG index and arterial stiffness as measured based on brachial ankle pulse wave velocity (baPWV) in Korean adults. METHODS: A total of 3587 subjects were enrolled in this study. Anthropometric and cardiovascular risk factors were measured. The TyG index was calculated as ln[fasting triglycerides(mg/dl) x fasting glucose(mg/dl)/2], and the insulin resistance index of homeostasis model assessment (HOMA-IR) was estimated. Arterial stiffness was determined by measuring baPWV. RESULTS: The subjects were stratified into four groups based on the TyG index. There were significant differences in cardiovascular parameters among the groups; the mean baPWV increased significantly with increasing TyG index. According to the logistic regression analysis after adjusting for multiple risk factors, the odds ratio (95% CI) for increased baPWV (> 75th percentile) for the highest and lowest quartiles of the TyG index was 2.92 (1.92-4.44) in men and 1.84 (1.15-2.96) in women, and the odds ratio for increased baPWV for the highest and lowest quartiles of the HOMA-IR was 1.80 (1.17-2.78) in men and 1.46 (1.06-2.47) in women, respectively. CONCLUSION: The TyG index is more independently associated with increased arterial stiffness than HOMA-IR in Korean adults.
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1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실)
Yonsei Authors
강신애(Kang, Shin Ae) ORCID logo https://orcid.org/0000-0002-9719-4774
김민진(Kim, Min Jin)
남지선(Nam, Ji Sun) ORCID logo https://orcid.org/0000-0001-8655-5258
박종숙(Park, Jong Suk) ORCID logo https://orcid.org/0000-0002-5385-1373
안철우(Ahn, Chul Woo)
유지홍(You, Ji Hong)
이병권(Lee, Byoung Kwon) ORCID logo https://orcid.org/0000-0001-9259-2776
이상배(Lee, Sang Bae) ORCID logo https://orcid.org/0000-0002-2998-6534
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